所有图片(1)
About This Item
经验公式（希尔记法）:
C17H15ClO2
CAS号:
分子量:
286.75
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
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质量水平
方案
≥98% (HPLC)
表单
powder
储存条件
protect from light
颜色
white to off-white
溶解性
DMSO: >20 mg/mL
储存温度
2-8°C
SMILES字符串
OC(=O)\C=C(\CCc1ccc(Cl)cc1)c2ccccc2
InChI
1S/C17H15ClO2/c18-16-10-7-13(8-11-16)6-9-15(12-17(19)20)14-4-2-1-3-5-14/h1-5,7-8,10-12H,6,9H2,(H,19,20)/b15-12-
InChI key
LLJYFDRQFPQGNY-QINSGFPZSA-N
生化/生理作用
PDK1（磷酸肌醇依赖性蛋白激酶1）激活剂，与HM/PIF结合口袋而不是ATP结合位点结合。
PS48是一种PDK1（磷酸肌醇依赖性蛋白激酶1）激活剂，可与HM/PIF结合口袋而不是ATP结合位点结合。PS48是靶向蛋白激酶催化结构域上与ATP结合位点不相邻或不重叠的调节结合位点的少数几种真正的变构化合物之一。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Reversible inhibition of the blood-testis barrier protein improves stem cell homing in mouse testes.
Mito Kanatsu-Shinohara et al.
The Journal of reproduction and development, 64(6), 511-522 (2018-09-04)
Stem cell homing is a complex phenomenon that involves multiple steps; thus far, attempts to increase homing efficiency have met with limited success. Spermatogonial stem cells (SSCs) migrate to the niche after microinjection into seminiferous tubules, but the homing efficiency
Satoshi Watanabe et al.
Biology of reproduction, 100(2), 523-534 (2018-08-31)
Spermatogonial stem cells (SSCs) provide the foundation of spermatogenesis. However, because of their small number and slow self-renewal, transfection of SSCs has met with limited success. Although several viral vectors can infect SSCs, genome integration and an inability to maintain
Shun Watanabe et al.
Pflugers Archiv : European journal of physiology, 468(4), 667-677 (2015-11-19)
Hyperinsulinemia associated with type 2 diabetes may contribute to the development of vascular diseases. Although we recently reported that enhanced contractile responses to serotonin (5-hydroxytryptamine, 5-HT) are observed in the arteries of type 2 diabetes models, the causative factors and
Risheng Ma et al.
Frontiers in endocrinology, 11, 446-446 (2020-08-08)
Background: The success in rescuing thyroid deficiency in mice using thyroid cells derived from embryonic stem (ES) cells, together with the discovery of human induced pluripotent stem cells (iPSCs) from somatic cells, has raised the possibility of patient-specific thyroid cell
Bethany R Mordhorst et al.
Molecular reproduction and development, 85(4), 290-302 (2018-02-03)
Somatic cell nuclear transfer is a valuable technique for the generation of genetically engineered animals, however, the efficiency of cloning in mammalian species is low (1-3%). Differentiated somatic cells commonly used in nuclear transfer utilize the tricarboxylic acid cycle and
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