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Merck
CN
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文件

O9390

Sigma-Aldrich

N-草酰基甘氨酸

≥98% (HPLC)

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About This Item

经验公式（希尔记法）:
C4H5NO5
CAS号:
5262-39-5
分子量:
147.09
MDL编号:
MFCD00913253
UNSPSC代码:
12352209
PubChem化学物质编号:
329818940
NACRES:
NA.77

质量水平

100

检测方案

≥98% (HPLC)

形式

solid

储存条件

desiccated

溶解性

deionized water: >10 mg/mL

储存温度

2-8°C

SMILES字符串

OC(=O)CNC(=O)C(O)=O

InChI

1S/C4H5NO5/c6-2(7)1-5-3(8)4(9)10/h1H2,(H,5,8)(H,6,7)(H,9,10)

InChI key

BIMZLRFONYSTPT-UHFFFAOYSA-N

生化/生理作用

N-草酰甘氨酸是 α-酮戊二酸依赖性酶的抑制剂，并且模仿初始步骤，但不引发羟基化过程。N-草酰甘氨酸已被用于抑制含有 Jumonji C 结构域的组蛋白赖氨酸去甲基化酶。

特点和优势

该化合物收录于受体分类和信号转导手册的《谷氨酸/GABA合成与代谢》页面。想要浏览手册的其他页面， 请单击此处。
这种化合物是基因调控和神经科学研究的特色产品。了解更多特色基因调控和神经科学产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302

危险分类

Acute Tox. 4 Oral

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

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Shan Shao et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(8), 10860-10870 (2020-06-28)
The tumor microenvironment (TME) is a crucial factor in cancer progression. In breast cancer, cancer-associated fibroblasts (CAFs) and the derived stromal components have been recognized as comprising the majority of the pathological structure of the TME. In this study, we
Gulzhan Raiymbek et al.
eLife, 9 (2020-03-21)
H3K9 methylation (H3K9me) specifies the establishment and maintenance of transcriptionally silent epigenetic states or heterochromatin. The enzymatic erasure of histone modifications is widely assumed to be the primary mechanism that reverses epigenetic silencing. Here, we reveal an inversion of this
Lisa P Elia et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 39(17), 3332-3344 (2019-01-31)
Deficient progranulin levels cause dose-dependent neurological syndromes: haploinsufficiency leads to frontotemporal lobar degeneration (FTLD) and nullizygosity produces adult-onset neuronal ceroid lipofuscinosis. Mechanisms controlling progranulin levels are largely unknown. To better understand progranulin regulation, we performed a genome-wide RNAi screen using
Nathaniel W Mabe et al.
Cell reports, 33(5), 108341-108341 (2020-11-05)
Dysregulated gene expression is a common feature of cancer and may underlie some aspects of tumor progression, including tumor relapse. Here, we show that recurrent mammary tumors exhibit global changes in gene expression and histone modifications and acquire dependence on
Xiongwen Cao et al.
Cell reports, 30(12), 4152-4164 (2020-03-27)
Histone methyl groups can be removed by demethylases. Although LSD1 and JmjC domain-containing proteins have been identified as histone demethylases, enzymes for many histone methylation states or sites are still unknown. Here, we perform a screening of a cDNA library
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