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生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
antigen ~35 kDa (non-glycosylated)
antigen ~50 kDa (glycosylated)
种属反应性
human
浓度
~1.0 mg/mL
技术
western blot: 1-2 μg/mL using whole extract of human HEK-293T cells expressing ORAI1
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... ORAI1(84876)
mouse ... Orai1(109305)
一般描述
ORAI calcium release-activated calcium modulator 1 (ORAI1) is the pore-forming subunit of the Ca2+ release-activated (CRAC) channel. The protein possesses four predicted transmembrane domains and intracellular amino and carboxyl-terminal domains. The ORAI1 gene is localized on human chromosome 12q24.31.
免疫原
synthetic peptide corresponding to amino acids 288-301 of human ORAI1, conjugated to KLH. The corresponding sequence differs by 2 amino acids in rat and mouse.
应用
Anti-ORAI1 antibody produced in rabbit has been used in immunohistochemistry and Western blotting.
生化/生理作用
ORAI calcium release-activated calcium modulator 1 (ORAI1) modulates Ca2+ entry into cells. The channel is activated by stromal interaction molecule-1 (STIM-1). Mutation in the gene encoding the protein has been linked to late-onset tubular aggregate myopathy and congenital miosis.
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
Yi-Chun Yeh et al.
Molecular and cellular biology, 35(8), 1341-1349 (2015-02-04)
In eukaryotic cells, calcium entry across the cell surface activates nuclear gene expression, a process critically important for cell growth and differentiation, learning, and memory and immune cell functions. In immune cells, calcium entry occurs through store-operated Ca(2+) release-activated Ca(2+)
Antibody-Mediated Targeting of the Orai1 Calcium Channel Inhibits T Cell Function
Jennifer H. Cox
PLoS ONE (2013)
Calcium Influx of Mast Cells Is Inhibited by Aptamers Targeting the First Extracellular Domain of Orai1
Renshan Sun
PLoS ONE (2016)
Yukari Endo et al.
Human molecular genetics, 24(3), 637-648 (2014-09-18)
The store-operated Ca(2+) release-activated Ca(2+) (CRAC) channel is activated by diminished luminal Ca(2+) levels in the endoplasmic reticulum and sarcoplasmic reticulum (SR), and constitutes one of the major Ca(2+) entry pathways in various tissues. Tubular aggregates (TAs) are abnormal structures
Microdeletion of 12q24.31: Report of a Girl With Intellectual Disability, Stereotypies, Seizures and Facial Dysmorphisms
Orazio Palumbo
American Journal of Medical Genetics. Part A (2014)
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