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生物来源
mouse
质量水平
重组
expressed in NSO cells
方案
>95% (SDS-PAGE)
表单
lyophilized powder
效能
25-50 ng/mL ED50
分子量
100 kDa by SDS-PAGE (reducing)
calculated mol wt 70.9 kDa
包装
pkg of 100 μg
杂质
endotoxin, tested
UniProt登记号
储存温度
−20°C
SMILES字符串
CCCCCCCCCCC#CCCCCCC(O)=O
InChI
1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-10,13-17H2,1H3,(H,19,20)
InChI key
XXUPLYBCNPLTIW-UHFFFAOYSA-N
基因信息
mouse ... Tnfrsf11b(18383)
一般描述
Osteoprotegerin (OPG) is a member of the TNFR (tumor necrosis factor receptor) superfamily that can act as a decoy receptor for RANKL (receptor activator of nuclear factor κ-B ligand) and TRAIL (tumor necrosis factor-related apoptosis-inducing ligand). The primary structure of OPG protein consists of seven distinct domains, four of which corresponds to the extracellular cysteine-rich domains of TNFR proteins and constitutes the soluble OPG. OPG is expressed in a wide variety of tissues including adult heart, lung, kidney and liver. It is secreted both as a monomeric and a dimeric protein.
生化/生理作用
Binding of soluble osteoprotegerin (OPG) to sRANKL (soluble receptor activator of nuclear factor κ-B ligand) inhibits osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, thereby leading to excess accumulation of bone and cartilage. Changes in the level of serum OPG are associated with atherosclerosis and cardiovascular disorders. It might also be associated with malignancy and plays a regulatory role in multiple myeloma, prostate, breast, bladder and gastric carcinoma. OPG plays a vital role in bone metabolism and is involved in inhibition of ovariectomy-associated bone loss in rats.
OPG is a soluble secreted member of the tumor necrosis factor receptor superfamily that lacks any apparent cell-association motifs. It regulates the formation of osteoclasts and is involved in the regulation of bone resorption and remodeling. Human and mouse OPG share approximately 84% and 94% amino acid sequence identity, respectively, with rat OPG.
Soluble secreted member of the tumor necrosis factor receptor superfamily that lacks any apparent cell-association motifs; regulates the formation of osteoclasts and is involved in the regulation of bone resorption and remodeling.
外形
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.
分析说明
The biological activity is measured by its ability to neutralize apoptosis of mouse L-929 cells treated with 50 ng/ml recombinant human TRAIL.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Osteoprotegerin secreted by inflammatory and invasive breast cancer cells induces aneuploidy, cell proliferation and angiogenesis.
Goswami S and Sharma-Walia N
BMC Cancer, 15:935 (2015)
Functions of RANKL/RANK/OPG in bone modeling and remodeling.
Boyce BF and Xing L.
Archives of Biochemistry and Biophysics, 473(2), 139-146 (2008)
Polymorphisms in three genes are associated with hemorrhagic stroke.
Liu W
Brain and Behavior, 5(11), e00395-e00395 (2015)
Osteoprotegerin: a novel secreted protein involved in the regulation of bone density.
Simonet WS
Cell, 89(2), 309-319 (1997)
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