O8137
Osteoprotegerin/Fc Chimera from mouse
>95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder
别名:
OCIF, OPG
产品名称
Osteoprotegerin/Fc Chimera from mouse, >95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder
InChI key
XXUPLYBCNPLTIW-UHFFFAOYSA-N
SMILES string
CCCCCCCCCCC#CCCCCCC(O)=O
InChI
1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-10,13-17H2,1H3,(H,19,20)
biological source
mouse
recombinant
expressed in NSO cells
assay
>95% (SDS-PAGE)
form
lyophilized powder
potency
25-50 ng/mL ED50
mol wt
100 kDa by SDS-PAGE (reducing)
calculated mol wt 70.9 kDa
packaging
pkg of 100 μg
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Quality Level
Gene Information
mouse ... Tnfrsf11b(18383)
Analysis Note
The biological activity is measured by its ability to neutralize apoptosis of mouse L-929 cells treated with 50 ng/ml recombinant human TRAIL.
Biochem/physiol Actions
Binding of soluble osteoprotegerin (OPG) to sRANKL (soluble receptor activator of nuclear factor κ-B ligand) inhibits osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, thereby leading to excess accumulation of bone and cartilage. Changes in the level of serum OPG are associated with atherosclerosis and cardiovascular disorders. It might also be associated with malignancy and plays a regulatory role in multiple myeloma, prostate, breast, bladder and gastric carcinoma. OPG plays a vital role in bone metabolism and is involved in inhibition of ovariectomy-associated bone loss in rats.
OPG is a soluble secreted member of the tumor necrosis factor receptor superfamily that lacks any apparent cell-association motifs. It regulates the formation of osteoclasts and is involved in the regulation of bone resorption and remodeling. Human and mouse OPG share approximately 84% and 94% amino acid sequence identity, respectively, with rat OPG.
Soluble secreted member of the tumor necrosis factor receptor superfamily that lacks any apparent cell-association motifs; regulates the formation of osteoclasts and is involved in the regulation of bone resorption and remodeling.
General description
Osteoprotegerin (OPG) is a member of the TNFR (tumor necrosis factor receptor) superfamily that can act as a decoy receptor for RANKL (receptor activator of nuclear factor κ-B ligand) and TRAIL (tumor necrosis factor-related apoptosis-inducing ligand). The primary structure of OPG protein consists of seven distinct domains, four of which corresponds to the extracellular cysteine-rich domains of TNFR proteins and constitutes the soluble OPG. OPG is expressed in a wide variety of tissues including adult heart, lung, kidney and liver. It is secreted both as a monomeric and a dimeric protein.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Osteoprotegerin secreted by inflammatory and invasive breast cancer cells induces aneuploidy, cell proliferation and angiogenesis.
Goswami S and Sharma-Walia N
BMC Cancer, 15:935 (2015)
Functions of RANKL/RANK/OPG in bone modeling and remodeling.
Boyce BF and Xing L.
Archives of Biochemistry and Biophysics, 473(2), 139-146 (2008)
Osteoprotegerin: a novel secreted protein involved in the regulation of bone density.
Simonet WS
Cell, 89(2), 309-319 (1997)
Polymorphisms in three genes are associated with hemorrhagic stroke.
Liu W
Brain and Behavior, 5(11), e00395-e00395 (2015)
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