Anti-OMP 兔抗

Olfactory marker protein (OMP) is a phylogenetically conserved cytoplasmic protein of unknown function expressed almost exclusively in mature olfactory sensory neurons, in essentially all vertebrate species. OMP is expressed in both the olfactory neuroepithelium and the olfactory nerve projection to the olfactory bulb. In perikaryon, OMP is produced and are transported to the dendrite and axon in the glomerular layer of the olfactory bulb.

Olfactory marker protein (OMP) is a phylogenetically conserved, 19kDa, cytoplasmic protein of unknown function expressed almost exclusively in mature olfactory sensory neurons, in essentially all vertebrate species. The gene encoding OMP is localized on rat chromosome 1. OMP expression is initially detected in rat and mouse embryo during the last trimester of gestation and reaches adult levels at 2-4 weeks postnatally. It has been suggested that OMP is a novel modulatory component of the odor detection signal transduction cascade that is developmentally and physiologically regulated.

synthetic peptide corresponding to amino acids 119-137 located near the C-terminus of rat OMP conjugated to KLH.

Anti-OMP antibody produced in rabbit has been used in immunohistochemistry.

Anti-OMP antibody produced in rabbit has been used in:

• immunoblotting
• double immunofluorescence
• staining

Olfactory marker protein (OMP) helps to modulate the formation and refinement of the olfactory glomerular map. OMP-deficient mice generated by gene targeting in embryonic stem (ES) cells are compromised in their ability to respond to odor stimuli. In the OMP-null mouse, in addition to reduced odorant response, the levels of neural tyrosine hydroxylase (TH) and neuropeptide cholecystokinin (CCK) are severely reduced. It has been suggested that OMP is a novel modulatory component of the odor detection signal transduction cascade that is developmentally and physiologically regulated.

0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。

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