生物来源
synthetic (organic)
质量水平
产品线
BioReagent
检测方案
≥97% (HPLC)
形式
powder
技术
cell culture | insect: suitable
cell culture | mammalian: suitable
溶解性
H2O: 100 mg/mL
储存温度
−20°C
SMILES字符串
OC(=O)CC(=O)C(O)=O
InChI
1S/C4H4O5/c5-2(4(8)9)1-3(6)7/h1H2,(H,6,7)(H,8,9)
InChI key
KHPXUQMNIQBQEV-UHFFFAOYSA-N
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相关类别
一般描述
草酰乙酸是一种二羧酸，存在于人体的每个细胞中。它是三羧酸（TCA）循环和糖异生的代谢中间体。
应用
草酰乙酸已用于评价对肌萎缩性侧索硬化症（ALS）模型超氧化物歧化酶1 (SOD1) G93A小鼠神经肌肉功能和寿命的影响。它还被用作杜氏改良Eagles培养基（DMEM）的补充剂，用于培养鸡成纤维细胞（DF-1）和化学永生化来角雄性肝癌（LMH）细胞，以进行功能验证实验。
生化/生理作用
草酰乙酸在中枢代谢中起重要作用。它可抑制琥珀酸脱氢酶，是线粒体代谢的一种关键调节剂。
相关产品
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Brian D Fink et al.
The Journal of biological chemistry, 293(51), 19932-19941 (2018-11-06)
We recently reported a previously unrecognized mitochondrial respiratory phenomenon. When [ADP] was held constant ("clamped") at sequentially increasing concentrations in succinate-energized muscle mitochondria in the absence of rotenone (commonly used to block complex I), we observed a biphasic, increasing then
Alexander Zlotnik et al.
Anesthesiology, 116(1), 73-83 (2011-12-02)
Decreasing blood glutamate concentrations after traumatic brain injury accelerates brain-to-blood glutamate efflux, leading to improved neurologic outcomes. The authors hypothesize that treatment with blood glutamate scavengers should reduce neuronal cell loss, whereas administration of glutamate should worsen outcomes. The authors
L T Wong et al.
Pediatric research, 20(3), 274-279 (1986-03-01)
An infant with the acute neonatal form of pyruvate carboxylase deficiency (cross-reacting material negative) presented with severe intractable lactic acidosis within 4 h after birth. He also had hyperammonemia, hypercitrullinemia, and hyperlysinemia. Plasma glutamine was not elevated. He had a
Tonya N Zeczycki et al.
Biochemistry, 50(45), 9724-9737 (2011-10-01)
The catalytic mechanism of the MgATP-dependent carboxylation of biotin in the biotin carboxylase domain of pyruvate carboxylase from R. etli (RePC) is common to the biotin-dependent carboxylases. The current site-directed mutagenesis study has clarified the catalytic functions of several residues
Lee Hua Long et al.
Biochemical and biophysical research communications, 417(1), 446-450 (2011-12-15)
Several phenolic compounds as well as ascorbate can oxidise in certain cell culture media (especially Dulbecco's modified Eagle's medium (DMEM)) to generate hydrogen peroxide. Addition of oxaloacetate decreased the levels of H(2)O(2) detected and the oxaloacetate was depleted. Oxaloacetate was
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