O7635
抗-骨桥蛋白 山羊抗
affinity isolated antibody, lyophilized powder
别名:
抗-OPN
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关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA (c), IHC, Neutral, WB
Citations:
6
biological source
goat
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
species reactivity
mouse
technique(s)
capture ELISA: 0.2-0.8 μg/mL, immunohistochemistry: 5-15 μg/mL using mouse thymus tissue sections, neutralization: 1-3 μg/mL, western blot: 0.1-0.2 μg/mL
UniProt accession no.
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
mouse ... Spp1(20750)
General description
OPN（骨桥蛋白）基因定位于小鼠染色体5 E5，可编码分泌性磷蛋白1，主要表达于骨组织。
Immunogen
在NSO细胞中表达的纯化重组小鼠骨桥蛋白。
Biochem/physiol Actions
骨桥蛋白(OPN)主要充当不少整合素受体的配体，与细胞迁移、趋化、侵袭和存活有关。研究发现，OPN基因在前列腺癌、乳腺癌等肿瘤中均有上调，并参与致病过程。OPN通过介导脂肪细胞炎症和巨噬细胞激活后的胰岛素抵抗而与肥胖症关联。OPN可作为胞外信号转导的效应分子，促进纤维化和肌细胞生长。
Physical form
从含有5％海藻糖的磷酸盐缓冲生理盐水的0.2μm过滤的溶液中冻干。
Analysis Note
使用293细胞中和重组小鼠骨桥蛋白的生物活性。
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
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