推荐产品
质量水平
检测方案
≥98% (HPLC)
形式
powder
溶解性
1 M NaOH: 49.00-51.00 mg/mL, clear to slightly hazy, colorless to yellow (heated NaOH)
SMILES字符串
O=C1NC(=O)c2cn[nH]c2N1
InChI
1S/C5H4N4O2/c10-4-2-1-6-9-3(2)7-5(11)8-4/h1H,(H3,6,7,8,9,10,11)
InChI key
HXNFUBHNUDHIGC-UHFFFAOYSA-N
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应用
氧嘌呤醇已被用作黄嘌呤氧化酶抑制剂，以评估其对肝癌细胞增殖的影响。它也已被用作黄嘌呤抑制剂，以阐明其在诱导hpv16晚期基因表达中的作用。
氧嘌呤醇是一种别嘌呤醇代谢产物，被用作抑制剂来研究黄嘌呤氧化酶的特异性和动力学。氧嘌呤醇还通过抑制黄嘌呤氧化酶而用作抗炎药。
生化/生理作用
氧嘌呤醇具有刺激成骨细胞分化和增强骨形成的能力。用于治疗痛风和高尿酸血症。氧嘌呤醇被认为是一种强抗氧化剂。它能阻止成骨细胞黄嘌呤氧化酶（XO）的作用。
一种别嘌醇的代谢产物。
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Allopurinol and oxypurinol promote osteoblast differentiation and increase bone formation
Orriss I R, et al.
Experimental Cell Research, 342(2), 166-174 (2016)
Xanthine dehydrogenase downregulation promotes TGF beta signaling and cancer stem cell-related gene expression in hepatocellular carcinoma
Chen GL, et al.
Oncogenesis, 6(9), e382-e382 (2017)
Umair Z Malik et al.
Free radical biology & medicine, 51(1), 179-184 (2011-05-11)
Xanthine oxidase (XO) is a critical source of reactive oxygen species (ROS) that contribute to vascular inflammation. Binding of XO to vascular endothelial cell glycosaminoglycans (GAGs) results in significant resistance to inhibition by traditional pyrazolopyrimidine-based inhibitors such as allopurinol. Therefore
Sophie L Stocker et al.
British journal of clinical pharmacology, 74(3), 477-489 (2012-02-04)
Our aim was to identify and quantify the sources of variability in oxypurinol pharmacokinetics and explore relationships with plasma urate concentrations. Non-linear mixed effects modelling was applied to concentration-time data from 155 gouty patients with demographic, medical history and renal
Paolo Puddu et al.
Journal of cardiology, 59(3), 235-242 (2012-03-09)
Uric acid is the end product of purine metabolism. Its immediate precursor, xanthine, is converted to uric acid by an enzymatic reaction involving xanthine oxidoreductase. Uric acid has been formerly considered a major antioxidant in human plasma with possible beneficial
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