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Merck
CN
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文件

O5889

Sigma-Aldrich

Opipramol dihydrochloride

≥98% (HPLC), solid

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别名:
4-[3-(5H-Dibenz[b,f]azepin-5-yl)propyl]-1-piperazineethanol dihydrochloride
经验公式（希尔记法）:
C23H29N3O · 2HCl
CAS号:
909-39-7
分子量:
436.42
EC 号:
213-000-2
MDL编号:
MFCD00941483
UNSPSC代码:
12352200
PubChem化学物质编号:
24724565
NACRES:
NA.77

质量水平

100

检测方案

≥98% (HPLC)

形式

solid

储存条件

desiccated

颜色

yellow

溶解性

H2O: ~24 mg/mL

SMILES字符串

Cl[H].Cl[H].OCCN1CCN(CCCN2c3ccccc3C=Cc4ccccc24)CC1

InChI

1S/C23H29N3O.2ClH/c27-19-18-25-16-14-24(15-17-25)12-5-13-26-22-8-3-1-6-20(22)10-11-21-7-2-4-9-23(21)26;;/h1-4,6-11,27H,5,12-19H2;2*1H

InChI key

DLTOEESOSYKJBK-UHFFFAOYSA-N

相关类别

一般描述

Opipramol acts as an antidepressant and is chemically similar to tricyclic antidepressants. It is an atypical anxiolytic and antidepressant drug. Opipramol mainly acts on sigma receptors. It is usually found to be much effective in depressive disorder. It has the ability to prevent histamine, serotonin, dopamine and alpha-1 adrenergic receptors.

生化/生理作用

σ1/σ2 opioid receptor agonist; an antagonist at D2, 5HT2 and H1 receptors; atypical antidepressant, antipsychotic and anxiolytic

象形图

Exclamation markEnvironment
GHS07,GHS09

警示用语：

Warning

危险声明

H302,H410

危险分类

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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Hakan Dursun et al.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 129(7), 861-869 (2009-07-03)
Tricyclic antidepressants are particularly useful in the treatment of endogenous depression. Since the 1950s, tricyclic antidepressants (TCAs) have also been used for the treatment of gastric ulcer disease. Many TCAs have been evaluated for their antiulcer effects, but there are
H J Möller et al.
Journal of clinical psychopharmacology, 21(1), 59-65 (2001-02-24)
Opipramol, a drug widely prescribed in Germany, is a tricyclic compound with no reuptake-inhibiting properties. However, it has pronounced D2-, 5-HT2-, and H1-blocking potential and high affinity to sigma receptors (sigma-1 and sigma-2). In early controlled trials, anxiolytic effects were
[Opipramol in behavioral pharmacologic anxiety and depression models].
C Gentsch
Fortschritte der Neurologie-Psychiatrie, 66 Suppl 1, S17-S20 (1999-01-29)
Update Opipramol
Gahr M, et al.
Fortschritte der Neurologie-Psychiatrie, 139-145 (2017)
Opipramol as nighttime medication.
Ulrich Leutgeb
Deutsches Arzteblatt international, 106(18), 321-321 (2009-06-24)
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