推荐产品
Amino Acid Sequence
Tyr-Leu-Tyr-Gln-Trp-Leu-Gly-Ala-Pro-Val-Pro-Tyr-Pro-Asp-Pro-Leu-Gla-Pro-Arg-Arg-Gla-Val-Cys-Gla-Leu-Asn-Pro-Asp-Cys-Asp-Glu-Leu-Ala-Asp-His-Ile-Gly-Phe-Gln-Glu-Ala-Tyr-Arg-Arg-Phe-Tyr-Gly-Pro-Val [Disulfide Bridge: 23-29]
一般描述
骨γ-羧基谷氨酸蛋白(BGLAP)或骨钙素(OCN)是由成骨细胞分泌的非胶原骨基质蛋白。含Gla（γ羧基谷氨酸）结构域。骨钙素编码基因位于人染色体1q22上。
牙质和可能其他矿化组织中发现的钙结合蛋白。
应用
人骨钙素（片段1-49）已被用于鉴定和表征骨钙素的糖化加合物。也用于研究其对小鼠成肌细胞系C2C12分化的影响。
生化/生理作用
骨γ-羧基谷氨酸蛋白（BGLAP，骨钙素）可调节间充质干细胞的成骨分化。在骨的转换和矿化中起作用。还在能量代谢中起作用。骨钙素(BGLAP)可能是介导骨组织与葡萄糖代谢的因子。
包装
无底玻璃瓶。内含物在插入的融合锥体内。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Analysis of the Influence of Hormone Replacement Therapy on Osteocalcin Gene Expression in Postmenopausal Women
Mansur Rahnama
BioMed Research International (2015)
Identification and characterization of glycation adducts on osteocalcin
Corinne J
Analytical Biochemistry (2017)
Serum Levels of Osteocalcin and Insulin Resistance in Patients with Impaired Glucose Tolerance or New-Onset Diabetes Mellitus After Liver Transplantation.
Martinez-Diaz-Guerra G
Hormone and Metabolic Research, 48(5), 325-330 (2016)
Serum Levels of Osteocalcin and Insulin Resistance in Patients with Impaired Glucose Tolerance or New-Onset Diabetes Mellitus After Liver Transplantation.
Martinez-Diaz
Hormone and Metabolic Research (2016)
Hua Shen et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 30(4), 596-605 (2014-10-29)
It is well-established that muscle forces are necessary for bone development as well as proper bone modeling and remodeling. Recent work has also suggested that bone acts as an endocrine organ that can influence the development of other organs. Connexin43
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