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生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
种属反应性
human
存货情况
not available in Japan
技术
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 14 μg/mL using human brain tissue
UniProt登记号
运输
dry ice
储存温度
−20°C
基因信息
human ... HCRTR1(3061)
mouse ... Hcrtr1(230777)
rat ... Hcrtr1(25593)
免疫原
OX1R / Orexin Receptor 1 antibody was raised against synthetic 16 amino acid peptide from C-terminus of human HCRTR1 / Orexin Receptor 1
生化/生理作用
Orexin is a neuropeptide that modulates the energy and metabolism balance. The effects of orexin are mediated by one of the two G protein-coupled receptors, orexin receptor 1 or 2. OXRs are expressed in oxinergic projection areas of the brain and regulate food intake by reducing systemic and brain signals that drive over-eating.
外形
Solution in phosphate buffered saline containing 0.1% sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Yonghua Chen et al.
Frontiers in cellular neuroscience, 13, 478-478 (2019-11-12)
Airway vagal nerves play a predominant role in the neural control of the airway, and augmented airway vagal activity is known to play important roles in the pathogenesis of some chronic inflammatory airway diseases. Several lines of evidence indicate that
Thomas E Fitch et al.
Frontiers in neuroscience, 8, 5-5 (2014-01-31)
We describe a novel, potent and selective orexin-2 (OX2)/hypocretin-2 receptor antagonist with in vivo activity in an animal model predictive of antidepressant-like efficacy. N-biphenyl-2-yl-4-fluoro-N-(1H-imidazol-2-ylmethyl) benzenesulfonamide HCl (LSN2424100) binds with high affinity to recombinant human OX2 receptors (Ki = 4.5 nM)
Michel A Steiner et al.
Frontiers in pharmacology, 4, 165-165 (2014-01-15)
The orexin system regulates feeding, nutrient metabolism and energy homeostasis. Acute pharmacological blockade of orexin receptor 1 (OXR-1) in rodents induces satiety and reduces normal and palatable food intake. Genetic OXR-1 deletion in mice improves hyperglycemia under high-fat (HF) diet
Zi-Bing Liu et al.
Clinical and experimental pharmacology & physiology, 37(10), 963-968 (2010-06-10)
1. Orexins are neuropeptides synthesized in the hypothalamus that regulate many physiological functions, including energy homeostasis, stress responses, sleep/wake states etc. It is now emerging that orexins may also regulate breathing, but little is known as to how they do
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