O4264
Human Osteopontin
recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture
别名:
OPN, 分泌磷蛋白1 (Spp1), 早期T淋巴细胞活化蛋白-1（ETA-1）, 骨唾液蛋白-1
产品名称
骨桥蛋白 人, recombinant, expressed in NSO cells, ≥95% (SDS-PAGE), lyophilized powder, suitable for cell culture
biological source
human
recombinant
expressed in NSO cells
sterility
sterile
assay
≥95% (SDS-PAGE)
form
lyophilized powder
mol wt
60-65 kDa by SDS-PAGE (reducing)
packaging
pkg of 50 μg
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
UniProt accession no.
shipped in
ambient
storage temp.
−20°C
Quality Level
Gene Information
human ... SPP1(6696)
Analysis Note
通过测量固定蛋白支持HEK293人胚胎肾细胞的粘附能力来确定生物活性。有效粘附作用的ED50为0.100-0.600 g/ml。
Application
兔抗骨桥蛋白抗体已用于ELISA。
Biochem/physiol Actions
一种分泌的高酸性钙结合磷酸化糖蛋白，对巨噬细胞、平滑肌细胞、内皮细胞和神经胶质细胞具有趋化性。在活化的巨噬细胞中，OPN抑制一氧化氮的产生和细胞毒性。人，小鼠，大鼠，猪和牛OPN具有40%的氨基酸序列同一性。分泌的磷蛋白1（SPP1）或骨桥蛋白调节炎症反应和葡萄糖代谢。它是一种趋化因子，在免疫细胞募集中起作用。该蛋白还与细胞生长，迁移和分化有关。SPP1将破骨细胞附着到骨基质上。它也参与动脉粥样硬化过程和骨矿化。它是许多癌症的标志物。
General description
分泌的磷蛋白1（SPP1）或骨桥蛋白是一种分泌的细胞因子。这种磷酸化的酸性糖蛋白在各种细胞和组织中表达。由成骨细胞合成。编码SPP1的基因位于人染色体4q22.1上。
Physical form
从含有2.5 mg牛血清白蛋白的磷酸盐缓冲盐中的0.2 μm过滤溶液中冻干。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
含少量动物源组分生物产品
常规特殊物品
此项目有
Osteopontin Fragments with Intact Thrombin-Sensitive Site Circulate in Cervical Cancer Patients
Danny TM
PLoS ONE (2016)
Polycystic ovary syndrome is associated with increased osteopontin levels
European Journal of Endocrinology (2015)
Expanded comparative mapping between man
and rabbit and detection of a new conserved
segment between HSA22 and OCU4
and rabbit and detection of a new conserved
segment between HSA22 and OCU4
C Chantry
Cytogenetic and genome research (2005)
Osteopontin-a possible anchor of osteoclasts to bone
FINN P. REINHOLT
Proceedings of the National Academy of Sciences of the USA (1990)
Osteopontin That Is Elevated in the Airways during COPD Impairs the Antibacterial Activity of Common Innate Antibiotics
Anele Gela
PLoS ONE (2016)
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