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质量水平
检测方案
≥95% (HPLC)
形式
powder
技术
HPLC: suitable
颜色
white to off-white
储存温度
−20°C
SMILES字符串
CC(N1)=NC=C(C[N+]2=CSC(CCO)=C2C)C1=O.Cl.[Cl-]
InChI
1S/C12H16N3O2S.2ClH/c1-8-11(3-4-16)18-7-15(8)6-10-5-13-9(2)14-12(10)17;;/h5,7,16H,3-4,6H2,1-2H3,(H,13,14,17);2*1H
InChI key
QHUYPZVMEJLSEB-UHFFFAOYSA-N
一般描述
羟基硫胺素是一种硫胺素抗代谢物，其饮食来源是通过摄入富含硫胺素的酸性食品。
应用
羟基硫胺素盐酸盐适用于：
- 作为参考标准品用于生成液相色谱-串联质谱（LC-MS/MS）的校准曲线定量测定红细胞中的羟基硫胺素焦磷酸盐 (OTPP)
- 作为人乳腺上皮细胞 (HMEC) 和乳腺癌细胞系中的硫胺素运输抑制剂
- 合成羟基硫胺素H苦酮酸盐
生化/生理作用
羟基硫胺素（OT）是一种硫胺素拮抗剂。它是一种转酮醇酶抑制剂，用于研究抗转移机制，尤其是涉及金属蛋白酶（MMP）的机制。它可以显著提高人肝癌细胞（HCC）对索拉非尼的敏感性，从而有利于肿瘤抑制。
羟乙胺抑制转酮醇酶，即控制戊糖磷酸途径非氧化分支的酶。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Chih-Min Yang et al.
Clinical & experimental metastasis, 27(5), 341-349 (2010-05-08)
This study examined the anti-metastatic effects of oxythiamine (OT) both in cell culture and in vivo. Cell culture results revealed that OT (0-20 microM) significantly inhibited the invasion and migration (IC(50) = 8.75 microM) of Lewis lung carcinoma (LLC) cells.
Hengwei Zhang et al.
Journal of proteome research, 9(2), 980-989 (2009-12-29)
Oxythiamine (OT), a transketolase inhibitor, is known to inhibit pancreatic cancer cell proliferation. In this study, we investigated the effect of inhibition of the transketolase pathway on signaling pathways in MIA PaCa cancer cells using in-house proteomic techniques. We hypothesized
Thiamine antimetabolite causes functional thiamine deficiency in patients with end stage renal disease
Zhang F, et al.
Kidney International, 90(2), 396-403 (2016)
Functional thiamine deficiency in end-stage renal disease: malnutrition despite ample nutrients
Moradi H and Said HM
Kidney International, 90(2), 252-254 (2016)
Inhibition of transketolase by oxythiamine altered dynamics of protein signals in pancreatic cancer cells
Wang J, et al.
Experimental Hematology & Oncology, 2(1), 18-18 (2013)
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