推荐产品
产品名称
Osteopontin from bovine milk, lyophilized powder
生物来源
bovine milk
质量水平
无菌性
sterile
表单
lyophilized powder
分子量
~60 kDa
包装
pkg of 50 μg
技术
cell culture | mammalian: suitable
运输
ambient
储存温度
−20°C
基因信息
cow ... SPP1(281499)
一般描述
Osteopontin (OPN) is a multifunctional protein. It is released by macrophages, T cells and epithelial cells. It has 261 amino acid residues with a molecular mass of 29,283 Da. Osteopontin is also called as uropontin. Osteopontin from bovine milk is highly glycosylated and phosphorylated. SPP1 gene (secreted phosphoprotein 1) codes for osteopontin. This gene is located on human chromosome 4 and cow chromosome 6. It has seven exons and six introns.
生化/生理作用
A secreted, highly acidic, calcium binding, phosphorylated glycoprotein that is chemotactic for macrophages, smooth muscle cells, endothelial cells, and glial cells. In activated macrophages, OPN inhibits nitric oxide production and cytotoxicity. Human, mouse, rat, pig, and bovine OPN share 40% amino acid sequence identity.
Osteopontin stimulates cell mediated responses, chemotaxis of inflammatory cells and anti-inflammatory responses. It binds to av-containing integrins and stimulate cell adhesion and migration. Osteopontin promotes Th1 type immunity.
外形
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 2.5 mg bovine serum albumin.
分析说明
The biological activity is measured by its ability to mediate 293 cell adhesion.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
动植物源性产品
Molecular analysis of the Bacillus subtilis bacteriophage SPP1 region encompassing genes 1 to 6: The products of gene 1 and gene 2 are required for pac cleavage.
Chai S, et al.
Journal of Molecular Biology, 224(1), 87-102 (1992)
Milk and Milk Products in Human Nutrition (2011)
Milk Proteins: From Expression to Food (2014)
Guidebook to the Extracellular Matrix, Anchor, and Adhesion Proteins (1999)
D D Hu et al.
The Journal of biological chemistry, 270(44), 26232-26238 (1995-11-03)
Osteopontin (OPN) is an extracellular matrix protein that binds to integrin alpha v beta 3. Here we demonstrate that two other integrins, alpha v beta 1 and alpha v beta 5, are also receptors for OPN. Human embryonic kidney 293
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