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标记范围
3-6 mol ochratoxin A per mol BSA
质量水平
储存温度
2-8°C
SMILES字符串
O=C1O[C@H](C)CC2=C(Cl)C=C(C(N[C@H](C(O)=O)CC3=CC=CC=C3)=O)C(O)=C21
InChI
1S/C20H18ClNO6/c1-10-7-12-14(21)9-13(17(23)16(12)20(27)28-10)18(24)22-15(19(25)26)8-11-5-3-2-4-6-11/h2-6,9-10,15,23H,7-8H2,1H3,(H,22,24)(H,25,26)/t10-,15+/m1/s1
InChI key
RWQKHEORZBHNRI-BMIGLBTASA-N
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应用
Ochratoxin A−BSA conjugate from Aspergillus ochraceus has been used in carbonate-bicarbonate buffer to coat the high-affinity 96-well polystyrene plates for indirect competitive enzyme-linked immunosorbent assay. It has also been used as a standard in the determination of ochratoxin A in serum by capillary electrophoresis with laser-induced fluorescence detection (CE-LIF).
生化/生理作用
Ochratoxin A (OTA) is a mycotoxin that is the most toxic among the other ochratoxins. It is produced by Aspergillus carbonarius, A. ochraceus, and Penicillium verrucosum. OTA acts as a major food contaminant and is considered nephrotoxic, teratogenic, neurotoxic, hepatotoxic, and immunotoxic. OTA is known to elevate oxidative stress at a cellular level.
警示用语：
Danger
危险分类
Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Carc. 1B - Repr. 1B
WGK
WGK 3
个人防护装备
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
新产品
Production of an ochratoxin A antigen with high hapten/carrier molar ratio.
H Worsaae
Acta pathologica et microbiologica Scandinavica. Section C, Immunology, 86C(4), 203-204 (1978-08-01)
Benedikt Cramer et al.
Bioorganic & medicinal chemistry, 18(1), 343-347 (2009-11-19)
The mycotoxin ochratoxin A is a potent inhibitor of the protein biosynthesis and known to be cytotoxic in nanomolar concentrations. In order to investigate the relationship between stereochemistry and cytotoxicity of this compound, all four ochratoxin A stereoisomers have been
Maria-Teresa Gutierrez-Lugo et al.
Bioorganic & medicinal chemistry letters, 21(8), 2480-2483 (2011-03-12)
The cysteinyl transferase mycothiol ligase, or MshC, catalyzes the fourth step in the biosynthesis of the small molecular weight thiol mycothiol. MshC is essential for growth of Mycobacterium tuberculosis. Two groups of known aminoacyl tRNA synthetase inhibitors were evaluated for
Gregory Kaler et al.
The Journal of biological chemistry, 282(33), 23841-23853 (2007-06-08)
Organic anion transporters (OATs, SLC22) interact with a remarkably diverse array of endogenous and exogenous organic anions. However, little is known about the structural features that determine their substrate selectivity. We examined the substrate binding preferences and transport function of
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