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Amino Acid Sequence
H-Ile-Ser-Gln-Ala-Val-His-Ala-Ala-His-Ala-Glu-Ile-Asn-Glu-Ala-Gly-Arg-OH
一般描述
卵清蛋白（323-339）是由B细胞表位环绕的蛋清蛋白，被特异性IgE抗体结合。除此之外，它还含有CD4+ T细胞表位。
该肽是卵清蛋白的第II类主要MHC限制性T细胞表位，用于研究免疫性过敏反应，如哮喘、食物过敏等。
应用
卵清蛋白（323-339）（鸡，日本鹌鹑）已被用于诱导小鼠过敏性哮喘。
生化/生理作用
卵清蛋白（OVA）肽323-339在隔离的BALB/c小鼠体内介导25-35％的T细胞对完整OVA的反应。OVA 323-339被广泛用于测定第II类主要组织相容性复合体（MHC）-肽结合特征和T细胞活化特征。
在两个功能不同的辅助因子的帮助下，卵清蛋白（323-339）肽可与组织相容性复杂的II类I-A（d）蛋白结合。
外形
由0.1％ TFA水溶液冷冻干燥而得
其他说明
从0.1％ TFA的H2O溶液冷冻干燥而得
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Qian Zhou et al.
EMBO molecular medicine, 14(1), e14502-e14502 (2021-12-14)
Impressive clinical benefit is seen in clinic with PD-1 inhibitors on portion of cancer patients. Yet, there remains an urgent need to develop effective synergizers to expand their clinical application. Tumor-associated macrophage (TAM), a type of M2-polarized macrophage, eliminates or
S Sung et al.
Journal of immunology (Baltimore, Md. : 1950), 166(2), 1261-1271 (2001-01-06)
Dendritic cells (DC) are the primary APC responsible for the capture of allergens in the airways and the shuttling of processed allergens to the draining lymph nodes where Ag presentation and T cell activation take place. The mechanism of this
Ovalbumin(323-339) peptide binds to the major histocompatibility complex class II I-A(d) protein using two functionally distinct registers
McFarland BJ, et al.
Biochemistry, 38(50), 16663-16670 (1999)
ORMDL3 may participate in the pathogenesis of bronchial xn-epithelialmesenchymal-1e9l transition in asthmatic mice with airway remodeling
Cheng Q, et al.
Molecular Medicine Reports, 17(1), 995-1005 (2018)
Haruyo Nakajima-Adachi et al.
Bioscience, biotechnology, and biochemistry, 76(10), 1979-1981 (2012-10-11)
The epitopes for OVA323-339-specific CD4⁺T cells from OVA23-3 food allergy model and DO11.10 tolerant induction model mice were analyzed. We found that OVA23-3 CD4⁺T cells recognized the N-terminal region, showing strong proliferation and the Th2-phenotype, and that DO11.10 CD4⁺T cells
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