O0891
Oxymatrine
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关于此项目
经验公式（希尔记法）:
C15H24N2O2
化学文摘社编号:
分子量:
264.36
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI key
XVPBINOPNYFXID-LHDUFFHYSA-N
SMILES string
[O-][N+]12CCCC3CN4C(CCCC4=O)C(CCC1)C23
InChI
1S/C15H24N2O2/c18-14-7-1-6-13-12-5-3-9-17(19)8-2-4-11(15(12)17)10-16(13)14/h11-13,15H,1-10H2/t11-,12+,13+,15-,17?/m0/s1
assay
≥98% (HPLC)
form
powder
solubility
methanol: 10 mg/mL, clear, colorless
storage temp.
2-8°C
Quality Level
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Biochem/physiol Actions
Alkaloid isolated from Sophora flavescens. Antifribotic. Neuroprotective. Traditional chinese medicine used in the treatment against hepatitis B virus.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
涉药品监管产品
此项目有
Xiaopei Yuan et al.
Journal of ethnopharmacology, 137(3), 1477-1485 (2011-09-01)
The combination of Radix Angelicae sinensis (Oliv.) Diels and Radix Sophora flavescens Ait. was extensively used in traditional Chinese medicine to treat inflammatory diseases, such as acne, heart disease, and hepatitis. Sodium ferulate (SF) and oxymatrine (OMT) were effective component
Ruiying Wang et al.
Stem cell research & therapy, 10(1), 20-20 (2019-01-13)
Cardiotoxicity remains an important concern in drug discovery and clinical medication. Meanwhile, Sophora tonkinensis Gapnep. (S. tonkinensis) held great value in the clinical application of traditional Chinese medicine, but cardiotoxic effects were reported, with matrine, oxymatrine, cytisine, and sophocarpine being
Man Huang et al.
Journal of ethnopharmacology, 143(1), 228-235 (2012-07-04)
Oxymatrine is extracted from the traditional Chinese herb Sophora flavescens Ait, possesses anti-inflammatory, anti-oxidative and anti-apoptotic properties, and has been used for the treatment of chronic viral hepatitis and many other diseases. This study aimed to investigate the effects of
Yan-Yan Zhang et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 43(2), 626-635 (2017-09-26)
Doxorubicin-induced cardiac toxicity has been a major concern of oncologists and is considered the main restriction on its clinical application. Oxymatrine has shown potent anti-cancer, anti-fibrosis, and anti-oxidative effects. Recently, it has been reported that oxymatrine is protective against some
Kun Zhang et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 20(3-4), 343-350 (2012-12-12)
Oxymatrine (OMT) is a major bioactive component derived from Sophora flavescens Ait (kushen), which is widely used in Chinese medicine. Recent studies have shown that it has neuroprotective effects; however, its underlying mechanisms remain unclear. We focus on the mechanisms
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