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Merck
CN

O0891

Sigma-Aldrich

Oxymatrine

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经验公式(希尔记法):
C15H24N2O2
CAS号:
分子量:
264.36
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.25

检测方案

≥98% (HPLC)

质量水平

形式

powder

溶解性

methanol: 10 mg/mL, clear, colorless

储存温度

2-8°C

SMILES字符串

[O-][N+]12CCCC3CN4C(CCCC4=O)C(CCC1)C23

InChI

1S/C15H24N2O2/c18-14-7-1-6-13-12-5-3-9-17(19)8-2-4-11(15(12)17)10-16(13)14/h11-13,15H,1-10H2/t11-,12+,13+,15-,17?/m0/s1

InChI key

XVPBINOPNYFXID-LHDUFFHYSA-N

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生化/生理作用

Alkaloid isolated from Sophora flavescens. Antifribotic. Neuroprotective. Traditional chinese medicine used in the treatment against hepatitis B virus.

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

监管及禁止进口产品

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Xiaopei Yuan et al.
Journal of ethnopharmacology, 137(3), 1477-1485 (2011-09-01)
The combination of Radix Angelicae sinensis (Oliv.) Diels and Radix Sophora flavescens Ait. was extensively used in traditional Chinese medicine to treat inflammatory diseases, such as acne, heart disease, and hepatitis. Sodium ferulate (SF) and oxymatrine (OMT) were effective component
Man Huang et al.
Journal of ethnopharmacology, 143(1), 228-235 (2012-07-04)
Oxymatrine is extracted from the traditional Chinese herb Sophora flavescens Ait, possesses anti-inflammatory, anti-oxidative and anti-apoptotic properties, and has been used for the treatment of chronic viral hepatitis and many other diseases. This study aimed to investigate the effects of
Ruiying Wang et al.
Stem cell research & therapy, 10(1), 20-20 (2019-01-13)
Cardiotoxicity remains an important concern in drug discovery and clinical medication. Meanwhile, Sophora tonkinensis Gapnep. (S. tonkinensis) held great value in the clinical application of traditional Chinese medicine, but cardiotoxic effects were reported, with matrine, oxymatrine, cytisine, and sophocarpine being
Yan-Yan Zhang et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 43(2), 626-635 (2017-09-26)
Doxorubicin-induced cardiac toxicity has been a major concern of oncologists and is considered the main restriction on its clinical application. Oxymatrine has shown potent anti-cancer, anti-fibrosis, and anti-oxidative effects. Recently, it has been reported that oxymatrine is protective against some
Ning-Li Chai et al.
World journal of gastroenterology, 18(31), 4199-4206 (2012-08-25)
To investigate the potential mechanism of Arg-Gly-Asp (RGD) peptide-labeled liposome loading oxymatrine (OM) therapy in CCl₄-induced hepatic fibrosis in rats. We constructed a rat model of CCl₄-induced hepatic fibrosis and treated the rats with different formulations of OM. To evaluate

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