所有图片(1)
别名:
5,8-二氢-5-乙基-8-氧代-1,3-二氧戊环并[4,5-g]喹啉-7-羧酸
经验公式（希尔记法）:
C13H11NO5
CAS号:
分子量:
261.23
Beilstein:
620635
EC 号:
MDL编号:
UNSPSC代码:
51101500
PubChem化学物质编号:
NACRES:
NA.85
推荐产品
质量水平
溶解性
0.5 M NaOH: soluble 50 mg/mL
抗生素抗菌谱
Gram-negative bacteria
作用机制
DNA synthesis | interferes
enzyme | inhibits
储存温度
2-8°C
SMILES字符串
CCN1C=C(C(O)=O)C(=O)c2cc3OCOc3cc12
InChI
1S/C13H11NO5/c1-2-14-5-8(13(16)17)12(15)7-3-10-11(4-9(7)14)19-6-18-10/h3-5H,2,6H2,1H3,(H,16,17)
InChI key
KYGZCKSPAKDVKC-UHFFFAOYSA-N
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一般描述
化学结构：喹诺酮
应用
恶喹酸被用于研究大肠杆菌（Escherichia coli）和肠沙门氏菌（Salmonella enterica）中的新型传染性抗性机制qnrA、qnrB、qnrS和aac(6′)Ib-cr。将恶喹酸加入培养基中，可用于分离阴道加德纳菌（Gardnerella vaginalis）。
生化/生理作用
恶喹酸是一种喹诺酮类抗生素。它是一种DNA促旋酶（拓扑异构酶II）抑制剂，可用于研究DNA缠绕和卷曲，并作为多巴胺再摄取抑制剂，用于多巴胺能神经传递过程的研究。
其他说明
5g,25g
保存于密闭容器内，置于干燥通风处。
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
农药列管产品
J Garcia de Mateos-Verchere et al.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 8(4), 255-259 (1999-02-03)
The antimicrobial agent oxolinic acid, injected i.p. in mice, induced a dose dependent increase in locomotor activity. This stimulation culminated at the 32 mg/kg dose and became smaller for higher doses (64-128 mg/kg). When opposed to increasing doses (50-100-200 microg/kg
J S Thompson
Journal of clinical microbiology, 21(5), 843-843 (1985-05-01)
Colistin-oxolinic acid medium is proposed as a selective isolation medium for Gardnerella vaginalis. The medium is effective in inhibiting staphylococci and gram-negative bacteria while allowing growth of G. vaginalis.
Xiuhong Wang et al.
The Journal of antimicrobial chemotherapy, 65(3), 520-524 (2010-01-14)
Quinolone-mediated death of Escherichia coli has been proposed to occur by two pathways. One is blocked by inhibitors of protein synthesis; the other is not. It is currently unknown how these two pathways fit with the recent observation that hydroxyl
Alketa Tarushi et al.
Journal of inorganic biochemistry, 103(6), 898-905 (2009-04-28)
The neutral mononuclear zinc complexes with the quinolone antibacterial drug oxolinic acid in the absence or presence of a nitrogen donor heterocyclic ligand 2,2'-bipyridine or 1,10-phenanthroline have been synthesized and characterized. The experimental data suggest that oxolinic acid is on
Takashi Aoki et al.
Marine biotechnology (New York, N.Y.), 13(4), 629-638 (2010-04-16)
Shrimp aquaculture is one of the major foodproducing industries in the world. However, it is being impacted by several problems including diseases, antibiotic use, and environmental factors. The extent of the effects of these problems in the immune system of
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