O0391
奥洛他定 盐酸盐
≥98% (HPLC)
别名:
(11Z)-11- [3-（二甲氨基）亚丙基]-6,11-二氢二苯并 [b,e] 氧杂萘-2-乙酸 盐酸盐, AL-4943A, KW-4679, 奥洛他定, 帕坦诺
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关于此项目
经验公式（希尔记法）:
C21H23NO3·HCl
化学文摘社编号:
分子量:
373.87
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Quality Level
assay
≥98% (HPLC)
form
solid
solubility
H2O: ≥20 mg/mL
storage temp.
room temp
SMILES string
Cl.CN(C)CC\C=C1\c2ccccc2COc3ccc(CC(O)=O)cc13
InChI
1S/C21H23NO3.ClH/c1-22(2)11-5-8-18-17-7-4-3-6-16(17)14-25-20-10-9-15(12-19(18)20)13-21(23)24;/h3-4,6-10,12H,5,11,13-14H2,1-2H3,(H,23,24);1H/b18-8-;
InChI key
HVRLZEKDTUEKQH-NOILCQHBSA-N
Gene Information
human ... HRH1(3269)
Biochem/physiol Actions
奥洛他定是一种双效组胺 H1 受体拮抗剂和肥大细胞稳定剂。
奥洛他定是一种组胺 H1 受体拮抗剂和肥大细胞稳定剂。大脑中的 H1 受体占位级别较低解释了奥洛他定镇静作用较低的原因。一般认为奥洛他定是 P-糖蛋白的底物，限制了其脑渗透。
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Aquatic Acute 1
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Eli O Meltzer et al.
Allergy and asthma proceedings, 32(3), 213-220 (2011-04-12)
Allergic rhinitis (AR) is highly prevalent in children. Olopatadine, 0.6% nasal spray (olopatadine) is approved for the relief of seasonal allergic rhinitis (SAR) symptoms in children 6 years of age and older. The objective of this study is to provide
Fuad M Baroody et al.
American journal of rhinology & allergy, 27(1), 48-53 (2013-02-15)
Nasal allergen challenge (NAC) leads to a nasal ocular reflex, which is augmented by allergic inflammation. This study was designed to confirm our previous observation that an intranasal steroid inhibits the nasal ocular reflex and to show that histamine does
Masahiko Shimura et al.
American journal of ophthalmology, 151(4), 697-702 (2011-01-25)
To evaluate the effectiveness of pre-seasonal treatment with topical olopatadine on the reduction of clinical symptoms of seasonal allergic conjunctivitis (SAC). Prospective interventional case series. Eleven patients with SAC received topical olopatadine in one eye at least two weeks before
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| O0391-50MG | 04061833026557 |
| O0391-10MG | 04061834212621 |