所有图片(1)
别名:
(2S-(2-alpha,3-beta,4-beta,4a-beta))-3,4,4a,5-tetrahydro-2,3,4,7-tetrahydroxy-(1,3)Dioxolo(4,5-j)phenanthridin-6(2H)-one, 3,4,4a,5-Tetrahydro-2,3,4,7-tetrahydroxy-(1,3)dioxolo(4,5-j)phenanthridin-6(2H)-one, BRN 1087400, Lycoricidin-A, Lycoricidinol, NSC 266535
经验公式（希尔记法）:
C14H13NO7
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检测方案
≥98% (HPLC)
形式
powder
颜色
white to off-white
溶解性
DMSO: ≥10 mg/mL
储存温度
room temp
SMILES字符串
O[C@H]1C=C2[C@@H](NC(=O)c3c(O)c4OCOc4cc23)[C@H](O)[C@@H]1O
InChI
1S/C14H13NO7/c16-6-1-5-4-2-7-13(22-3-21-7)11(18)8(4)14(20)15-9(5)12(19)10(6)17/h1-2,6,9-10,12,16-19H,3H2,(H,15,20)/t6-,9+,10+,12-/m0/s1
InChI key
LZAZURSABQIKGB-AEKGRLRDSA-N
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生化/生理作用
Narciclasine is a Rho/Rho kinase/LIM kinase/cofilin signaling pathway activator. Also narciclasine is an actin stress fiber formation inducer; a plant growth modulator.
警示用语：
Danger
危险声明
预防措施声明
危险分类
Acute Tox. 3 Oral
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Xiaofan Na et al.
Journal of plant physiology, 168(11), 1149-1156 (2011-04-23)
Plant development displays an exceptional plasticity and adaptability that involves the dynamic, asymmetric distribution of the phytohormone auxin. Polar auxin flow, which requires transport facilitators of the PIN family, largely contributes to the establishment and maintenance of auxin gradients and
Gwendoline Van Goietsenoven et al.
Medicinal research reviews, 33(2), 439-455 (2012-03-16)
The anticancer activity of Amaryllidaceae isocarbostyrils is well documented. At pharmacological concentrations, that is, approximately 1 μM in vitro and approximately 10 mg/kg in vivo, narciclasine displays marked proapoptotic and cytotoxic activity, as does pancratistatin, and significant in vivo anticancer
George R Pettit et al.
Journal of natural products, 68(8), 1256-1258 (2005-08-30)
Bioassay (P388 lymphocytic leukemia cell line and human cancer cell lines) guided separation of an extract prepared from the previously chemically uninvestigated Texas grasshopper Brachystola magna led to isolation of the cancer cell growth inhibitory pancratistatin (1), narciclasine (2), and
Chemistry, biology, and medicinal potential of narciclasine and its congeners.
Alexander Kornienko et al.
Chemical reviews, 108(6), 1982-2014 (2008-05-21)
Gwendoline Van Goietsenoven et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 24(11), 4575-4584 (2010-07-21)
Melanomas display poor response rates to adjuvant therapies because of their intrinsic resistance to proapoptotic stimuli. This study indicates that such resistance can be overcome, at least partly, through the targeting of eEF1A elongation factor with narciclasine, an Amaryllidaceae isocarbostyril
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