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N9284

硝基还原酶来源于大肠杆菌

Name: 硝基还原酶 来源于<I>大肠杆菌</I>
Brand: SIGMA
Price: 1070.84 CNY
Availability: InStock

≥90% (SDS-PAGE), recombinant, expressed in E. coli

别名:

NTRA

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100 MG

¥1,070.84

1 G

¥8,487.98

¥1,070.84

国内现货，预计发货时间2025年4月27日详情

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100 MG

¥1,070.84

1 G

¥8,487.98

About This Item

MDL编号:

MFCD03457727

UNSPSC代码:

12352204

NACRES:

NA.54

¥1,070.84

国内现货，预计发货时间2025年4月27日详情

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此商品	T151	SML2686	T150
T144 (±)-Thalidomide	T151 (+)-Thalidomide	SML2686 THAL-SNS-032	T150 (−)-Thalidomide
assay ≥98%	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay >98%
form powder	form powder	form powder	form solid
solubility DMSO: 20 mg/mL, clear	solubility DMSO: 15 mg/mL, clear	solubility DMSO: 2 mg/mL, clear	solubility DMSO: soluble, H₂O: insoluble, ethanol: insoluble
originator Celgene	originator Celgene	originator -	originator Celgene
color white	color white to beige	color white to beige	color white
ligand thalidomide	ligand thalidomide	ligand pomalidomide	ligand thalidomide

一般描述

硝基还原酶是一种黄素蛋白，由NfsB基因编码。它包含一个二聚体，每个亚基具有217个氨基酸和活性位点。该结构具有FMN和与酶结合的底物。[1]

应用

大肠杆菌来源硝基还原酶可结合猪肝酯酶(PLE)用于偶联结合反应。[2]它还还可结合探针HyCL-3和HyCL-4-AM针对大鼠肝微粒体进行化学发光响应研究。[3]

生化/生理作用

硝基还原酶(NTR)可催化还原硝基芳香族底物和醌。[1]NTR的F124K突变体可用于癌症治疗，改善药物CB1954的敏化作用。[4]

硝基还原酶在NADPH或NADH为还原剂的氧还系统中有重要作用。 [5]

硝基还原酶增强了生命体对于含氮药物，比如甲硝唑的敏感度，它将氮基团转化为有毒的氮自由基。 [6]

能够还原奎宁。该酶可以激活抗体引导酶前药治疗的前药。

物理属性

含有PBS的冻干粉。作为辅药不含有BSA

单位定义

在pH7.4、37℃、存在甲萘醌和NADH的条件下，一单位酶每分钟能够还原1μmole细胞色素C。

制备说明

使用没有动物组分的材料生产。

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

常规特殊物品

技术规格说明书

历史批次信息供参考:

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Generation of Escherichia coli nitroreductase mutants conferring improved cell sensitization to the prodrug CB1954

Grove JI, et al.

Cancer research, 63(17), 5532-5537 (2003)

Analogs of nitrofuran antibiotics are potent GroEL/ES inhibitor pro-drugs.

Mckayla Stevens et al.

Bioorganic & medicinal chemistry, 28(22), 115710-115710 (2020-10-03)

In two previous studies, we identified compound 1 as a moderate GroEL/ES inhibitor with weak to moderate antibacterial activity against Gram-positive and Gram-negative bacteria including Bacillus subtilis, methicillin-resistant Staphylococcus aureus, Klebsiella pneumonia, Acinetobacter baumannii, and SM101 Escherichia coli (which has

Nitroreductase catalyzed biotransformation of CL-20.

Bharat Bhushan et al.

Biochemical and biophysical research communications, 322(1), 271-276 (2004-08-18)

Previously, we reported that a salicylate 1-monooxygenase from Pseudomonas sp. ATCC 29352 biotransformed CL-20 (2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaaza-isowurtzitane) (C(6)H(6)N(12)O(12)) and produced a key metabolite with mol. wt. 346 Da corresponding to an empirical formula of C(6)H(6)N(10)O(8) which spontaneously decomposed in aqueous medium to

Anaerobic bacteria as a gene delivery system that is controlled by the tumor microenvironment.

M J Lemmon et al.

Gene therapy, 4(8), 791-796 (1997-08-01)

A fundamental obstacle in gene therapy for cancer treatment is the specific delivery of an anticancer gene product to a solid tumor. Although several strategies exist to control gene expression once a vector is directly introduced into a tumor, as

Taiwanofungus camphorata nitroreductase: cDNA cloning and biochemical characterisation.

Chih-Chen Chen et al.

Food chemistry, 135(4), 2708-2713 (2012-09-18)

Nitroreductases (Nrs) play important roles in redox system via NADPH or NADH as a reductant. A TcNr cDNA encoding a putative Nr was cloned from Taiwanofungus camphorata. A 3-D structural model of the TcNr has been created based on the

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硝基还原酶来源于大肠杆菌

≥90% (SDS-PAGE), recombinant, expressed in E. coli

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