product name
Necrostatin-1, ≥98% (HPLC)
质量水平
检测方案
≥98% (HPLC)
形式
powder
溶解性
DMSO: >10 mg/mL
储存温度
−20°C
SMILES字符串
CN1C(=S)NC(Cc2c[nH]c3ccccc23)C1=O
InChI
1S/C13H13N3OS/c1-16-12(17)11(15-13(16)18)6-8-7-14-10-5-3-2-4-9(8)10/h2-5,7,11,14H,6H2,1H3,(H,15,18)
InChI key
TXUWMXQFNYDOEZ-UHFFFAOYSA-N
应用
Necrostatin-1已用于研究在小鼠体内肝损伤过程中及在体外肝星状细胞中，其对白介素（IL）-33表达的调节作用。在实验研究中，它还被用作受体相互作用蛋白激酶1（RIPK1）的抑制剂。
生化/生理作用
Necrostatin-1(Nec-1)可能对脑外伤 (TBI)患者具有治疗作用。另外，它还可用于治疗其他细胞死亡方式为神经坏死的急性中枢神经系统（CNS）疾病。它广泛用于研究实验疾病模型中受体相互作用蛋白激酶1 (RIPK1)对细胞死亡和炎症的影响。Nec-1通过提高细胞谷胱甘肽 (GSH)水平、减少活性氧产生，抑制凋亡诱导因子和B细胞淋巴瘤2（Bcl-2）的核转运以及B细胞淋巴瘤2（Bcl-2）/腺病毒E1B 19kDa互作蛋白3相关途径，从而保护海马（HT-22）细胞免受谷氨酸诱导的氧化作用。
Necrostatin-1是坏死性凋亡的抑制剂（非凋亡性细胞死亡途径）。
特点和优势
该化合物是细胞凋亡研究的推荐产品。点击此处，了解更多精选的细胞凋亡产品。了解更多有关用于其他研究领域的生物活性小分子的信息，请访问 sigma.com/discover-bsm。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Sorafenib-induced defective autophagy promotes cell death by necroptosis
Kharaziha P, et al.
Testing, 6(35), 37066-37066 (2015)
T Suzuki et al.
Canadian journal of biochemistry, 55(5), 521-527 (1977-05-01)
Proton magnetic resonance spectra of methylthiohydantoin (3-methyl-2-thiohydantoin), thiohydantoin (2-thiohydantoin), and hydantoin derivatives of amino acids were studied in dimethyl sulfoxide-d6. Their parent amino acids could be identified by the spectra. An application to the N- and C-terminal amino acid analysis
The chemical inhibitors of cellular death, PJ34 and Necrostatin-1, down-regulate IL-33 expression in liver
Arshad MI, et al.
Journal of Molecular Medicine, 93(8), 867-878 (2015)
Anahita Kyani et al.
ChemMedChem, 13(2), 164-177 (2017-12-14)
Protein disulfide isomerase (PDI) is overexpressed in glioblastoma, the most aggressive form of brain cancer, and folds nascent proteins responsible for the progression and spread of the disease. Herein we describe a novel nanomolar PDI inhibitor, pyrimidotriazinedione 35G8, that is
Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models
Takahashi N, et al.
Cell Death & Disease, 3(11), e437-e437 (2012)
商品
Apoptosis regulation involves multiple pathways and molecules for cellular homeostasis.
Cell cycle phases (G1, S, G2, M) regulate cell growth, DNA replication, and division in proliferating cells.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门