所有图片(2)
About This Item
经验公式（希尔记法）:
C8H8O4
CAS号:
分子量:
168.15
MDL编号:
UNSPSC代码:
12352202
PubChem化学物质编号:
NACRES:
NA.77
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表单
solid
SMILES字符串
O=C1OC(=O)C2C3CCC(O3)C12
InChI
1S/C8H8O4/c9-7-5-3-1-2-4(11-3)6(5)8(10)12-7/h3-6H,1-2H2
InChI key
JAABVEXCGCXWRR-UHFFFAOYSA-N
基因信息
human ... PPP2R5A(5525)
一般描述
去甲斑蝥素 (NCTD) 是斑蝥素 (CTD) 的脱甲基衍生物。
应用
去甲斑蝥素已被用于原代细胞培养和治疗。它还被用于皮下接种Huh7细胞的小鼠。
生化/生理作用
去甲斑蝥素是一种潜在的抗肿瘤药物。去甲斑蝥素通过刺激细胞自噬和凋亡来阻断 SK-N-SH 神经母细胞瘤细胞的生长。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
高风险级别生物产品--毒素类产品
Norcantharidin inhibits SK-N-SH neuroblastoma cell growth by induction of autophagy and apoptosis
Han Z, et al.
Technology in Cancer Research & Treatment, 16(1), 33-44 (2017)
C Y Hong et al.
Biochemical and biophysical research communications, 276(1), 278-285 (2000-09-28)
Norcantharidin (NCTD), a synthetic analogue of phosphatase type 2A inhibitors, cantharidin, was shown to have limited effects in treating human and animal tumors. The tumor cell killing mechanisms by norcantharidin, however, remain unclear. In this report, we wished to investigate
Norcantharidin modulates the miR-30a/Metadherin/AKT signaling axis to suppress proliferation and metastasis of stromal tumor cells in giant cell tumor of bone
Chen F, et al.
Biomedicine and Pharmacotherapy, 103, 1092-1100 (2018)
Chao-Bin Yeh et al.
PloS one, 7(2), e31055-e31055 (2012-03-01)
The rate of morbidity and mortality of hepatocellular carcinoma (HCC) in Taiwan has not lessened because of difficulty in treating tumor metastasis. Norcantharidin (NCTD) is currently used as an anticancer drug for hepatoma, breast cancer, and colorectal adenocarcinoma. NCTD possesses
Rebekah E Wharton et al.
Toxins, 11(12) (2019-12-19)
Microcystins (MC) and nodularin (NOD) are toxins released by cyanobacteria during harmful algal blooms. They are potent inhibitors of protein phosphatases 1 and 2A (PP1 and PP2A) and cause a variety of adverse symptoms in humans and animals if ingested.
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