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应用
- 通过ENU诱导的致突变和自动减数分裂图谱绘制识别的血压和心率的遗传决定因素。: 该研究利用N-乙基-N-亚硝基脲（ENU）诱导的致突变识别了影响血压和心率的遗传因子。该研究利用利用自动减数分裂图谱绘制来揭示这些心血管特性的遗传基础（Teixeira et al., 2024）。
- 从对照大鼠和N-乙基-N-亚硝基脲处理大鼠中分离的Hprt 突变T淋巴细胞的克隆性、运输和分子变化。: 该研究考察了ENU对小鼠中T淋巴细胞的克隆性和运输的作用。该研究发现提供了有关 ENU致突变和免疫影响的见解，有助于我们理解化学物质诱导的突变（Judice et al., 2023）。
- 采用双重测序（duplex sequencing）技术进行遗传毒性测试：研究人员采用接触N-乙基-N-亚硝基脲（ENU）的大鼠进行了概念验证致突变实验。: 该项概念验证研究结合了双重测序技术来测试接触ENU的大鼠的遗传毒性。结果表明了这种方法检测致突变作用的可行性和有效性，彰显了其在遗传毒性评估中的潜力（Smith-Roe et al., 2023）。
生化/生理作用
在许多动物种属中具有致癌性的 DNA 烷化剂。诱发多种类型的良性和恶性肿瘤，包括神经组织、胃、食管、胰腺、呼吸道、肠、淋巴网状组织、皮肤和肾脏。
包装
按干燥品计的重量。
警示用语：
Danger
危险分类
Acute Tox. 3 Oral - Carc. 1B - Repr. 1B
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Georgina Caruana et al.
PloS one, 8(3), e55429-e55429 (2013-03-08)
Mice harbouring gene mutations that cause phenotypic abnormalities during organogenesis are invaluable tools for linking gene function to normal development and human disorders. To generate mouse models harbouring novel alleles that are involved in organogenesis we conducted a phenotype-driven, genome-wide
Jinjun Dang et al.
Blood, 125(23), 3609-3617 (2015-04-10)
Alterations of genes encoding transcriptional regulators of lymphoid development are a hallmark of B-progenitor acute lymphoblastic leukemia (B-ALL) and most commonly involve PAX5, encoding the DNA-binding transcription factor paired-box 5. The majority of PAX5 alterations in ALL are heterozygous, and
Katherine R Bull et al.
The Journal of pathology, 233(1), 18-26 (2013-12-03)
The study of mutations causing the steroid-resistant nephrotic syndrome in children has greatly advanced our understanding of the kidney filtration barrier. In particular, these genetic variants have illuminated the roles of the podocyte, glomerular basement membrane and endothelial cell in
Peng Huang et al.
Journal of genetics and genomics = Yi chuan xue bao, 39(9), 421-433 (2012-10-02)
Zebrafish (Danio rerio) is a well-established vertebrate animal model. A comprehensive collection of reverse genetics tools has been developed for studying gene function in this useful organism. Morpholino is the most widely used reagent to knock down target gene expression
Katherine R Bull et al.
PLoS genetics, 9(1), e1003219-e1003219 (2013-02-06)
Forward genetics screens with N-ethyl-N-nitrosourea (ENU) provide a powerful way to illuminate gene function and generate mouse models of human disease; however, the identification of causative mutations remains a limiting step. Current strategies depend on conventional mapping, so the propagation
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DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.
DNA损伤和修复机制对于维持DNA完整性至关重要。细胞DNA的损伤与突变、癌症发展等有关。
Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
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