N8381
2-萘胺
powder
别名:
β-氨基萘, 2-氨基萘
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关于此项目
线性分子式:
C10H7NH2
化学文摘社编号:
分子量:
143.19
EC Number:
202-080-4
UNSPSC Code:
12352103
NACRES:
NA.25
PubChem Substance ID:
Beilstein/REAXYS Number:
3939429
MDL number:
InChI key
JBIJLHTVPXGSAM-UHFFFAOYSA-N
InChI
1S/C10H9N/c11-10-6-5-8-3-1-2-4-9(8)7-10/h1-7H,11H2
SMILES string
Nc1ccc2ccccc2c1
form
powder
bp
306 °C (lit.)
mp
111-113 °C (lit.)
density
1.061 g/mL at 25 °C (lit.)
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General description
2-萘胺是一种膀胱癌致癌物，主要存在于香烟烟雾中。
Application
2-萘胺已被用作测定氨肽酶A和氨肽酶N活性的底物。
Biochem/physiol Actions
环境致癌物；诱发膀胱癌。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 2 - Carc. 1A
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
危险化学品
此项目有
Shiho Ohnishi et al.
Japanese journal of cancer research : Gann, 93(7), 736-743 (2002-08-01)
2-Naphthylamine (2-NA), a bladder carcinogen, is contained in cigarette smoke. DNA adduct formation is thought to be a major cause of DNA damage by carcinogenic aromatic amines. We have investigated whether a metabolite of 2-NA, 2-nitroso-1-naphthol (NO-naphthol) causes oxidative DNA
Y Yasunaga et al.
Laboratory investigation; a journal of technical methods and pathology, 77(6), 677-684 (1998-01-14)
Epidemiologic studies have revealed an increased risk for development of transitional cell carcinoma (TCC) among dye workers/painters occupationally exposed to aromatic amines such as benzidine, beta-naphthylamine, orthotoluidine, and aniline. In the present study, p53 gene mutations in 26 patients with
A Fernández-Atucha et al.
Biology of sex differences, 8, 5-5 (2017-02-09)
Serum peptidases, such as angiotensin-converting enzyme (ACE), angiotensin-converting enzyme-2 (ACE2), neutral endopeptidase (NEP), aminopeptidase N (APN), and aminopeptidase A (APA), are important elements of the renin-angiotensin system (RAS). Dysregulation of these enzymes has been associated with hypertension and cardiovascular risk.
Dylan M Owen et al.
Nature communications, 3, 1256-1256 (2012-12-06)
Lipid microdomains are postulated to regulate many membrane-associated processes but have remained highly controversial. Here we provide the first direct evidence that the plasma membrane of intact, live cells is comprised of a sub-resolution mixture of approximately 76% ordered and
Joanna M Kwiatek et al.
PloS one, 8(2), e52960-e52960 (2013-02-08)
Visualization and quantification of lipid order is an important tool in membrane biophysics and cell biology, but the availability of environmentally sensitive fluorescent membrane probes is limited. Here, we present the characterization of the novel fluorescent dyes PY3304, PY3174 and
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