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表单
powder
沸点
306 °C (lit.)
mp
111-113 °C (lit.)
密度
1.061 g/mL at 25 °C (lit.)
SMILES字符串
Nc1ccc2ccccc2c1
InChI
1S/C10H9N/c11-10-6-5-8-3-1-2-4-9(8)7-10/h1-7H,11H2
InChI key
JBIJLHTVPXGSAM-UHFFFAOYSA-N
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一般描述
2-萘胺是一种膀胱癌致癌物，主要存在于香烟烟雾中。
应用
2-萘胺已被用作测定氨肽酶A和氨肽酶N活性的底物。
生化/生理作用
环境致癌物；诱发膀胱癌。
警示用语：
Danger
危险声明
危险分类
Acute Tox. 4 Oral - Aquatic Chronic 2 - Carc. 1A
储存分类代码
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
个人防护装备
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
危险化学品
Y Yasunaga et al.
Laboratory investigation; a journal of technical methods and pathology, 77(6), 677-684 (1998-01-14)
Epidemiologic studies have revealed an increased risk for development of transitional cell carcinoma (TCC) among dye workers/painters occupationally exposed to aromatic amines such as benzidine, beta-naphthylamine, orthotoluidine, and aniline. In the present study, p53 gene mutations in 26 patients with
Shiho Ohnishi et al.
Japanese journal of cancer research : Gann, 93(7), 736-743 (2002-08-01)
2-Naphthylamine (2-NA), a bladder carcinogen, is contained in cigarette smoke. DNA adduct formation is thought to be a major cause of DNA damage by carcinogenic aromatic amines. We have investigated whether a metabolite of 2-NA, 2-nitroso-1-naphthol (NO-naphthol) causes oxidative DNA
A Fernández-Atucha et al.
Biology of sex differences, 8, 5-5 (2017-02-09)
Serum peptidases, such as angiotensin-converting enzyme (ACE), angiotensin-converting enzyme-2 (ACE2), neutral endopeptidase (NEP), aminopeptidase N (APN), and aminopeptidase A (APA), are important elements of the renin-angiotensin system (RAS). Dysregulation of these enzymes has been associated with hypertension and cardiovascular risk.
Carlos de la Haba et al.
Biochimica et biophysica acta, 1828(2), 357-364 (2012-09-04)
Plasma membrane is one of the preferential targets of reactive oxygen species which cause lipid peroxidation. This process modifies membrane properties such as membrane fluidity, a very important physical feature known to modulate membrane protein localization and function. The aim
Carlos de la Haba et al.
Biochimica et biophysica acta, 1838(1 Pt B), 148-157 (2013-08-21)
Receptor-ligand binding is an essential interaction for biological function. Oxidative stress can modify receptors and/or membrane lipid dynamics, thus altering cell physiological functions. The aim of this study is to analyze how oxidative stress may alter receptor-ligand binding and lipid
商品
Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete.
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