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产品名称
Nerve Growth Factor from Vipera lebetina venom, NGF, lyophilized powder, suitable for cell culture
生物来源
Vipera Lebetina
质量水平
表单
lyophilized powder
效能
0.2-20 μg/mL ED50/EC50
质量
endotoxin tested
分子量
protein 32.5 kDa
包装
pkg of 0.1 mg
技术
cell culture | mammalian: suitable
杂质
<10 EU/vial
颜色
white to off-white
UniProt登记号
储存温度
−20°C
外形
Lyophilized from a 0.2 μm filtered solution in sodium acetate buffer.
制备说明
Isolated from the snake venom of V. lebetina.
分析说明
The biological activity of Nerve Growth Factor (NGF) from Vipera lebetina venom is measured in a cell proliferation assay using PC-12 cells.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
Giusi Prencipe et al.
Journal of immunology (Baltimore, Md. : 1950), 192(7), 3345-3354 (2014-03-04)
Nerve growth factor (NGF) levels are highly increased in inflamed tissues, but their role is unclear. We show that NGF is part of a regulatory loop in monocytes: inflammatory stimuli, while activating a proinflammatory response through TLRs, upregulate the expression
Lucy Hepburn et al.
Science (New York, N.Y.), 346(6209), 641-646 (2014-11-02)
Many key components of innate immunity to infection are shared between Drosophila and humans. However, the fly Toll ligand Spaetzle is not thought to have a vertebrate equivalent. We have found that the structurally related cystine-knot protein, nerve growth factor
Rachel T Uren et al.
Journal of neurochemistry, 129(4), 614-627 (2014-02-04)
Suppressor of cytokine signaling-2 (SOCS2) is a regulator of intracellular responses to growth factors and cytokines. Cultured dorsal root ganglia neurons from neonatal mice with increased or decreased SOCS2 expression were examined for altered responsiveness to nerve growth factor (NGF).
Yu-Jung Chang et al.
Biochimica et biophysica acta, 1830(8), 4130-4136 (2013-04-16)
Neurotrophins are important regulators for neural development and regeneration. Nerve growth factor (NGF) therapy has been tested in various models of neural injury and degeneration. However, whether NGF can reach target tissues and maintain effective concentration for a certain period
Federica De Angelis et al.
Journal of cellular physiology, 229(6), 783-790 (2013-10-30)
The peripheral application of the M2 cholinergic agonist arecaidine on sensory nerve endings shows anti-nociceptive properties. In this work, we analyze in vitro, the mechanisms downstream M2 receptor activation causing the analgesic effects, and in vivo the effects produced by
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