N8010
4-Nitrophenyl 4-guanidinobenzoate hydrochloride
protease substrate, ≥95.0% (TLC), powder
别名:
4-Guanidinobenzoic acid 4-nitrophenylester hydrochloride, NPGB, pNPGB
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所有图片(3)
About This Item
经验公式（希尔记法）:
C14H12N4O4 · HCl
CAS号:
分子量:
336.73
Beilstein:
8024554
EC 号:
MDL编号:
UNSPSC代码:
12352204
PubChem化学物质编号:
NACRES:
NA.32
推荐产品
产品名称
4-Nitrophenyl 4-guanidinobenzoate hydrochloride, protease inhibitor and substrate
质量水平
方案
≥95.0% (TLC)
表单
powder
溶解性
formic acid: soluble 49.00-51.00 mg/mL
储存温度
−20°C
SMILES字符串
Cl[H].NC(=N)Nc1ccc(cc1)C(=O)Oc2ccc(cc2)[N+]([O-])=O
InChI
1S/C14H12N4O4.ClH/c15-14(16)17-10-3-1-9(2-4-10)13(19)22-12-7-5-11(6-8-12)18(20)21;/h1-8H,(H4,15,16,17);1H
InChI key
PKSBDZOBYIKNGY-UHFFFAOYSA-N
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一般描述
4-Nitrophenyl 4-guanidinobenzoate hydrochloride (pNPGB) is a trypsin substrate. It is more water-soluble than 4-methylumbelliferyl 4-guanidinobenzoate and is preferred in spectrophotometric assay.
应用
4-Nitrophenyl 4-guanidinobenzoate hydrochloride has been used:
- as a substrate for trypsin for active site titration experiments
- for pre-treating of mosquito eggs in the interplasmid transposition assay
- as a component of isotonic buffer to moisten filter paper for mosquito embryo collection
生化/生理作用
4-Nitrophenyl 4-guanidinobenzoate hydrochloride (pNPGB) inhibits phenoloxidase enzyme and delays embryo chorionic membrane hardening.
警示用语：
Danger
危险声明
危险分类
Eye Dam. 1
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
N Tomiya et al.
FEBS letters, 193(1), 44-48 (1985-11-25)
Acyl-plasmin-streptokinase complex has advantages as a 'site' directed fibrinolytic agent with the active site protected from the plasma protease inhibitors. But, in clinical use, the fibrinolytic potential of this acyl-enzyme complex is modified or abolished by the presence of streptokinase
S P Leytus et al.
Biochimica et biophysica acta, 788(1), 74-86 (1984-07-17)
A theory and experimental method are presented to characterize the kinetics of fast-acting, irreversible proteinase inhibitors. The theory is based upon formal analysis of the case of an irreversible inhibitor competing with a substrate for the active-site of a proteinase.
D Collen et al.
The Journal of biological chemistry, 268(11), 8284-8289 (1993-04-15)
The mechanism of activation of human plasminogen by recombinant staphylokinase (STAR) was studied using the active site titrant p-nitrophenyl-p'-guanidinobenzoate (NPGB). NPGB prevented active site exposure in equimolar mixtures of plasminogen and STAR but reacted stoichiometrically with mixtures preincubated in the
Qiuxiang Pang et al.
Fish & shellfish immunology, 17(5), 477-487 (2004-08-18)
The presence of phenoloxidase (PO) activity in the humoral fluid of amphioxus Branchiostoma belcheri tsingtauense was electrophoretically and spectrophotometrically studied. The enzyme was present in the humoral fluid predominantly as an inactive proenzyme, prophenoloxidase (proPO). The optimum temperature for activation
Agnieszka Jendroszek et al.
Thrombosis and haemostasis, 117(9), 1688-1699 (2017-08-05)
Plasminogen activator inhibitor type 1 (PAI-1) is a central regulator of fibrinolysis and tissue remodelling. PAI-1 belongs to the serpin superfamily and unlike other inhibitory serpins undergoes a spontaneous inactivation process under physiological conditions, termed latency transition. During latency transition
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