所有图片(2)
About This Item
经验公式（希尔记法）:
C11H14NO9P
CAS号:
分子量:
335.20
MDL编号:
UNSPSC代码:
12352106
PubChem化学物质编号:
NACRES:
NA.79
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生物来源
animal
质量水平
方案
≥98.0% (HPLC)
表单
powder
技术
HPLC: suitable
颜色
white
储存温度
−20°C
SMILES字符串
OC1C(O)C(OC1COP(O)(O)=O)[N]2=CC(=CC=C2)C(O)=O
InChI
1S/C11H15NO9P/c13-8-7(5-20-22(17,18)19)21-10(9(8)14)12-3-1-2-6(4-12)11(15)16/h1-4,7-10,13-14H,5H2,(H,15,16)(H2,17,18,19)
InChI key
IUJWGLOJJKFASX-UHFFFAOYSA-N
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一般描述
烟酸单核苷酸（NaMN）是在存在磷酸核糖基转移酶（NaPRT）的情况下，由烟酸5-磷酸核糖基-1-焦磷酸（PRPP）通过Preiss-Handler途径形成的。
应用
烟酸单核苷酸已被用作烟酰胺腺嘌呤二核苷酸（NAD）生物合成过程中NMN / NaMN腺苷转移酶（NMNAT）的底物。
生化/生理作用
烟酸单核苷酸（NaMN）可用于研究酵母中磷酸盐响应信号（PHO）途径与烟碱腺嘌呤二核苷酸（NAD（+））代谢之间的关系。 烟酸酯单核苷酸是NMN / NaMN腺苷转移酶（NMNAT）和烟酸酯单核苷酸腺苷转移酶的底物。NaMN酰胺化导致烟酰胺单核苷酸（NMN）的合成，其可进一步转化为NAD辅因子。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
William B Black et al.
Microbial cell factories, 19(1), 150-150 (2020-07-29)
Noncanonical redox cofactors are emerging as important tools in cell-free biosynthesis to increase the economic viability, to enable exquisite control, and to expand the range of chemistries accessible. However, these noncanonical redox cofactors need to be biologically synthesized to achieve
V Sharma et al.
Structure (London, England : 1993), 6(12), 1587-1599 (1998-12-24)
. Mycobacterium tuberculosis is the single most deadly human pathogen and is responsible for nearly three million deaths every year. Recent elucidation of the mode of action of isoniazid, a frontline antimycobacterial drug, suggests that NAD metabolism is extremely critical
Shu-Ping Lu et al.
The Journal of biological chemistry, 286(16), 14271-14281 (2011-02-26)
Nicotinamide adenine dinucleotide (NAD(+)) is an essential cofactor involved in various cellular biochemical reactions. To date the signaling pathways that regulate NAD(+) metabolism remain unclear due to the dynamic nature and complexity of the NAD(+) metabolic pathways and the difficulty
J C Eads et al.
Structure (London, England : 1993), 5(1), 47-58 (1997-01-15)
Quinolinic acid (QA) is a neurotoxin and has been shown to be present at high levels in the central nervous system of patients with certain diseases, such as AIDS and meningitis. The enzyme quinolinic acid phosphoribosyltransferase (QAPRTase) provides the only
Kazuo Yamada et al.
Analytical biochemistry, 352(2), 282-285 (2006-04-01)
We have developed a liquid chromatographic-tandem mass spectrometric method that is sensitive and specific and that simultaneously measures cellular NAD(+) and related compounds. Using this method, NAD(+), NAAD, NMN, NAMN, NAM, NA, ADPR, and 5'AMP were first separated over a
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