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质量水平
方案
≥98% (HPLC)
表单
solid
储存条件
protect from light
颜色
red
溶解性
DMSO: ≥10 mg/mL
H2O: insoluble
储存温度
2-8°C
SMILES字符串
ClC1=C(NCCN2CCOCC2)C(=O)c3ncccc3C1=O
InChI
1S/C15H16ClN3O3/c16-11-13(18-4-5-19-6-8-22-9-7-19)15(21)12-10(14(11)20)2-1-3-17-12/h1-3,18H,4-9H2
InChI key
BMKPVDQDJQWBPD-UHFFFAOYSA-N
基因信息
human ... CDC25B(994) , DUSP3(1845) , PTPN1(5770)
应用
NSC 663284 has been used as a cell division cycle 25 (CDC25) inhibitor to study its effects on the level of kizuna (kiz) dephosphorylation. It has also been used as a control in horseradish peroxidase/phenol red based assay and resazurin-based redox assay.
生化/生理作用
NSC 663284 is a quinolinediones, which is involved in the inhibition of cell cycle progression at both G1 and G2/M phase. It is also involved in inhibiting the dephosphorylation and activation of cyclin-dependent kinases (Cdks) in vitro and in vivo. NSC 663284 stops the proliferation of various tumor cell lines.
Potent, irreversible, cell permeable and mixed competitive CDC25 phosphatase family inhibitor
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
470.1 °F
闪点(°C)
243.4 °C
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Utility of resazurin, horseradish peroxidase, and NMR assays to identify redox-related false-positive behavior in high-throughput screens
Tarnowski M, et al.
Assay and Drug Development Technologies, 16(3), 171-191 (2018)
Inhibition of DUSP13B Activity by NSC 663284
Lee I S, et al.
Bulletin of the Korean Chemical Society,, 33(10), 3505-3507 (2012)
Kizuna is a novel mitotic substrate for CDC25B phosphatase
Thomas Y, et al.
Cell Cycle, 13(24), 3867-3877 (2014)
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