N7410
还原型 β-烟酰胺腺嘌呤二核苷酸 二钠盐
~98%, pkg of 2 mg (per vial)
别名:
β-DPNH, β-NADH, Coenzyme I reduced 二钠盐, Diphosphopyridine nucleotide reduced 二钠盐
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关于此项目
经验公式（希尔记法）:
C21H27N7Na2O14P2
化学文摘社编号:
分子量:
709.40
UNSPSC Code:
41106305
NACRES:
NA.51
PubChem Substance ID:
EC Number:
210-123-3
Beilstein/REAXYS Number:
5230241
MDL number:
Form:
solid
Assay:
~98%
InChI key
QRGNQKGQENGQSE-QUWMEQBESA-L
InChI
1S/C21H29N7O14P2.2Na/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33;;/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25);;/q;2*+1/p-2/t10-,11+,13-,14+,15-,16+,20-,21+;;/m0../s1
SMILES string
[Na+].[Na+].NC(=O)C1=CN(C=CC1)[C@H]2O[C@@H](COP([O-])(=O)OP([O-])(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n4cnc5c(N)ncnc45)[C@H](O)[C@@H]2O
assay
~98%
form
solid
packaging
pkg of 2 mg (per vial)
storage temp.
room temp
Quality Level
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Application
β-Nicotinamide adenine dinucleotide (NAD+) and β-Nicotinamide adenine dinucleotide, reduced (NADH) comprise a coenzyme redox pair (NAD+:NADH) involved in a wide range of enzyme catalyzed oxidation reduction reactions. In addition to its redox function, NAD+/NADH is a donor of ADP-ribose units in ADP-ribosylaton (ADP-ribosyltransferases; poly(ADP-ribose) polymerases ) reactions and a precursor of cyclic ADP-ribose (ADP-ribosyl cyclases).
Biochem/physiol Actions
电子供体
Preparation Note
溶液应新鲜制备并及时使用。
Other Notes
根据 UV-Vis 测定的 NADH 含量包装。
这是 NADH 的常见形式；不要与 α 混淆-NADH。
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
Eyeshields, Gloves, type N95 (US)
Amy Swanston et al.
Nucleic acids research, 47(12), 6172-6183 (2019-05-21)
Topoisomerase II (Top2) is an essential enzyme that decatenates DNA via a transient Top2-DNA covalent intermediate. This intermediate can be stabilized by a class of drugs termed Top2 poisons, resulting in massive DNA damage. Thus, Top2 activity is a double-edged
Qiuju Ding et al.
Life (Basel, Switzerland), 10(9) (2020-09-26)
With the advent of next generation sequencing, the list of mitochondrial DNA (mtDNA) mutations identified in patients rapidly and continuously expands. They are frequently found in a limited number of cases, sometimes a single individual (as with the case herein
Maali Odeh et al.
The FEBS journal, 287(1), 73-93 (2019-09-24)
Physiological or pathological muscle disuse/inactivity or loss of the neural-muscular junction cause muscle atrophy. Atrophy-inducing conditions cause metabolic oxidative stress in the muscle tissue, activation of the ubiquitin-proteasome and of the autophagosome-lysosome systems, enhanced removal of the damaged proteins and
Michael O Hottiger
FEBS letters, 585(11), 1595-1599 (2011-03-23)
ADP-ribosylation is a covalent post-translational protein modification catalyzed by ADP-ribosyltransferases and is involved in important processes such as cell cycle regulation, DNA damage response, replication or transcription. Histones are ADP-ribosylated by ADP-ribosyltransferase diphtheria toxin-like 1 at specific amino acid residues
Andreas Grahnert et al.
Innate immunity, 17(2), 212-233 (2010-04-15)
Latterly, nicotinamide adenine dinucleotide (NAD+) has emerged as a molecule with versatile functions and of enormous impact on the maintenance of cell integrity. Besides playing key roles in almost all major aspects of energy metabolism, there is mounting evidence that
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