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About This Item
经验公式（希尔记法）:
C9H8N2O2
CAS号:
分子量:
176.17
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
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质量水平
方案
≥97% (HPLC)
表单
solid
颜色
off-white
溶解性
DMSO: soluble >20 mg/mL
H2O: insoluble
储存温度
−20°C
SMILES字符串
CC1=Nc2c(O)cccc2C(=O)N1
InChI
1S/C9H8N2O2/c1-5-10-8-6(9(13)11-5)3-2-4-7(8)12/h2-4,12H,1H3,(H,10,11,13)
InChI key
YJDAOHJWLUNFLX-UHFFFAOYSA-N
基因信息
mouse ... Parp2(11546)
生化/生理作用
NU-1025 is a PARP inhibitor.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
Evangelos Koustas et al.
Journal of cellular and molecular medicine, 24(18), 10420-10431 (2020-07-21)
Gastric cancer is the fifth most common malignancy and the third leading cause of cancer-related death worldwide. Activation of c-MET increases tumour cell survival through the initiation of the DNA damage repair pathway. PARP is an essential key in the
David Zada et al.
Molecular cell, 81(24), 4979-4993 (2021-11-20)
The characteristics of the sleep drivers and the mechanisms through which sleep relieves the cellular homeostatic pressure are unclear. In flies, zebrafish, mice, and humans, DNA damage levels increase during wakefulness and decrease during sleep. Here, we show that 6 h
Quanju Zhao et al.
Journal of immunology (Baltimore, Md. : 1950), 198(7), 2935-2942 (2017-02-22)
IL-12 and IL-23 are important host defense factors produced by APCs against certain intracellular and extracellular pathogens. Their dysregulation has also been implicated in several autoimmune diseases. The nucleotide polymorphism in the promoter region of Il12b (rs41292470 consisting of the
Michael M Murata et al.
Molecular biology of the cell, 30(20), 2584-2597 (2019-08-08)
DNA damage signaling is critical for the maintenance of genome integrity and cell fate decision. Poly(ADP-ribose) polymerase 1 (PARP1) is a DNA damage sensor rapidly activated in a damage dose- and complexity-dependent manner playing a critical role in the initial
Yang Sun et al.
American journal of respiratory cell and molecular biology, 51(6), 738-749 (2014-05-31)
Lymphangioleiomyomatosis (LAM) is a female-predominant cystic lung disease that can lead to respiratory failure. LAM cells typically have inactivating tuberous sclerosis complex 2 (TSC2) mutations and mammalian target of rapamycin (mTOR) complex (mTORC) 1 activation. Clinical response to the mTORC1
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