推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
IgG fraction of antiserum
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen 150-160 kDa
种属反应性
human, rat
技术
microarray: suitable
western blot: 1:10,000 using rat brain extract
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... NOS1(4842)
rat ... Nos1(24598)
一般描述
Nitric Oxide Synthase, Brain (NOS1) is mapped to human chromosome 12q24.22. The NOS isoform found in neurons is a 150 kDa protein. It is also termed as brain NOS (bNOS). Human bNOS and endothelial NOS (eNOS) share 52% amino acid identity, and rat and human bNOS share 93% amino acid identity.
免疫原
synthetic peptide corresponding to nitric oxide synthase (NOS) of rat brain origin (bNOS, amino acids 251-270) conjugated to KLH. The immunogen sequence is highly conserved in human bNOS.
应用
Anti-Nitric Oxide Synthase, Brain (251-270) antibody produced in rabbit has been used in:
- double immunolabelling,
- immunofluorescence
- western blotting
生化/生理作用
Nitric Oxide Synthase, Brain (bNOS) is present also in skeletal muscle, where it is complexed with dystrophin and is absent in Duchenne muscular dystrophy (DMD). Neuronal and endothelial NOS are constitutively expressed and are dependent on Ca2+ calmodulin for nitric oxide (NO) production.
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Endothelial and neuronal nitric oxide synthases are present in the suprachiasmatic nuclei of Syrian hamsters and rats
Caillol M, et al.
The European Journal of Neuroscience, 12(2), 649-661 (2000)
Therapeutic strategies to address neuronal nitric oxide synthase deficiency and the loss of nitric oxide bioavailability in Duchenne Muscular Dystrophy
Timpani CA, et al.
Orphanet Journal of Rare Diseases, 12(1), 100-100 (2017)
A melon pulp concentrate rich in superoxide dismutase reduces stress proteins along the gastrointestinal tract of pigs
Lalles JP, et al.
Nutrition, 27(3), 358-363 (2011)
Expression of nitric oxide synthase in the retina of monocular deprivation amblyopia rats
Wang QM, et al.
European Review for Medical and Pharmacological Sciences, 22(7), 1879-1883 (2018)
nNOS-expressing neurons in the ventral tegmental area and substantia nigra pars compacta
Paul EJ, et al.
eNeuro, 5(5), 100-100 (2018)
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