biological source
mouse
recombinant
expressed in NSO cells
assay
>95% (SDS-PAGE)
form
lyophilized powder
mol wt
55-60 kDa by SDS-PAGE (reducing), calculated mol wt 50 kDa
packaging
pkg of 50 μg
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Quality Level
Gene Information
mouse ... Nog(18121)
Biochem/physiol Actions
Binds and blocks the acitivity of bone morphogenetic proteins (BMPs).
Binds and blocks the acitivity of bone morphogenetic proteins (BMPs). Mature mouse noggin shares 99% and 83% sequence identity with human and Xenopus noggin, respectively.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.
Analysis Note
The biological activity is measured by its ability to inhibit recombinant human BMP-4 induced alkaline phosphatase activity in ATDC5 cells.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
此项目有
TGF-beta superfamily members and ovarian follicle development.
Knight PG and Glister C
Reproduction (Cambridge, England) (2006)
Noggin antagonism of BMP4 signaling controls development of the axial skeleton in the mouse.
Wijgerde M
Developmental Biology (2005)
A H Reddi
Arthritis research, 3(1), 1-5 (2001-02-15)
This commentary is a concise discussion of the interactions between bone morphogenetic proteins (BMPs) and their binding proteins in bone and cartilage morphogenesis. BMPs are a family of growth and differentiation factors, and they act on mesenchymal cells to induce
Human disease-causing NOG missense mutations: effects on noggin secretion, dimer formation, and bone morphogenetic protein binding.
Marcelino J
Proceedings of the National Academy of Sciences of the USA (2001)
Impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis in noggin-overexpressing mice.
Wu XB
The Journal of Clinical Investigation (2003)
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