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N6383

神经降压素

Name: 神经降压素
Brand: SIGMA
Price: 3876.66 CNY

≥90% (HPLC)

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18 L

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18 L

¥3,876.66

About This Item

经验公式（希尔记法）:

C₇₈H₁₂₁N₂₁O₂₀

CAS号:

58889-67-1

分子量:

1672.92

MDL编号:

MFCD00076678

UNSPSC代码:

51111800

PubChem化学物质编号:

329818664

NACRES:

NA.32

¥3,876.66

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Sigma-Aldrich

A9650

人血管紧张素 I 乙酸盐水合物

Sigma-Aldrich

A9525

血管紧张素II，人

Sigma-Aldrich

05-23-1200

Neurotensin

Sigma-Aldrich

N5764

乳酸链球菌肽来源于乳酸乳球菌

Sigma-Aldrich

M2272

蜂毒肽来源蜜蜂毒液

Sigma-Aldrich

N5266

Neurotensin Fragment 8-13 acetate salt

Sigma-Aldrich

A2407

Adrenocorticotropic Hormone Fragment 1-17 human, rat

Sigma-Aldrich

B0125

杆菌肽

Sigma-Aldrich

L9133

亮氨酸脑啡肽乙酸盐水合物

Sigma-Aldrich

I6383

氧化胰岛素链 B 来源于牛胰腺

质量水平

200

方案

≥90% (HPLC)

表单

powder

UniProt登记号

P30990

储存温度

−20°C

SMILES字符串

CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]5CCC(=O)N5)C(=O)N[C@@H](CC(C)C)C(O)=O

InChI

1S/C78H121N21O20/c1-7-43(6)63(73(115)96-57(76(118)119)37-42(4)5)97-70(112)55(39-45-21-25-47(101)26-22-45)95-72(114)59-18-13-35-99(59)75(117)52(16-11-33-86-78(83)84)90-64(106)48(15-10-32-85-77(81)82)89-71(113)58-17-12-34-98(58)74(116)51(14-8-9-31-79)91-69(111)56(40-60(80)102)94-66(108)50(28-30-62(104)105)88-68(110)54(38-44-19-23-46(100)24-20-44)93-67(109)53(36-41(2)3)92-65(107)49-27-29-61(103)87-49/h19-26,41-43,48-59,63,100-101H,7-18,27-40,79H2,1-6H3,(H2,80,102)(H,87,103)(H,88,110)(H,89,113)(H,90,106)(H,91,111)(H,92,107)(H,93,109)(H,94,108)(H,95,114)(H,96,115)(H,97,112)(H,104,105)(H,118,119)(H4,81,82,85)(H4,83,84,86)/t43-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,63-/m0/s1

InChI key

PCJGZPGTCUMMOT-ISULXFBGSA-N

基因信息

human ... NTS(4922)

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此商品	PHR1075	SML1493	E2535
C4522 西咪替丁	PHR1075 西咪替丁	SML1493 Suprafenacine	E2535 Eprosartan mesylate
form powder	form -	form powder	form powder
Quality Level 200	Quality Level 300	Quality Level -	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. room temp
originator GlaxoSmithKline	originator -	originator -	originator Abbott
Gene Information human ... ABCB1(5243), CYP1A2(1544), CYP3A4(1576), HRH2(3274), SLC9A2(6549), SLC9A5(6553) mouse ... Abcb1a(18671), Abcb1b(18669) rat ... Slc9a1(24782), Slc9a3(24784), Slc9a5(192215)	Gene Information human ... HRH2(3274)	Gene Information -	Gene Information human ... AGTR1(185)

Amino Acid Sequence

Glp-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu

一般描述

Neurotensin (NT) is encoded by the gene mapped to human chromosome 12q21.31.[1] The encoded protein is a tridecapeptide with pGlu–Leu–Tyr–Glu–Asn–Lys–Pro–Arg–Arg–Pro–Tyr–Ile–Leu–COOH amino acid sequence.[2] NT is widely distributed in the gastrointestinal (GI) tract and central nervous system (CNS), but at high levels in hypothalamus, amygdala and nucleus accumbens as well as at low levels in peripheral blood.[1][3]

应用

Neurotensin has been used as an external calibration reagent in spectrum calibration.[4] It has also been used to evaluate the performance of online capillary electrophoresis to matrix-assisted laser desorption ionization (CE-MALDI).[5]

Neurotensin has been used in apoptosis/ cell death assay and is used in:

matrix-assisted laser desorption/ionisation-time of flight (MALDI-TOF) mass spectrometry analysis[6][7][8]

生化/生理作用

Neurotensin (NT) acts as an inducer for analgesia, hypothermia and hyperglycemia, and is an inhibitor of gastric motility. Plasma NT levels are high in children with Prader–Willi syndrome (PWS).[1] NT secreted from small cell lung cancer cells might have a regulatory action in this disease.[9] It has been implicated in regulation of gastric system and inflammatory processes in the lung. In addition, NT also regulates immune response by stimulating cytokine release and chemotaxis on interaction with leukocytes, peritoneal mast cells and dendritic cells.[3] NT present in gastrointestinal (GI) tract plays a vital role in various processes such as stimulation of pancreatic and biliary secretion and enhances growth of various normal tissues. It is involved downstream of Wnt/β-catenin signaling pathway and stimulates the growth of neuroendocrine tumor cells.[10]

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

监管及禁止进口产品

技术规格说明书

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Autohydrolysis of a partially cyclized mu/nu-carrageenan and structural elucidation of the oligosaccharides by chemical analysis, NMR spectroscopy and UV-MALDI mass spectrometry

Ciancia M, et al.

ARKIVOC (Gainesville, FL, United States), 12, 319-331 (2005)

Proneurotrophin-3 may induce Sortilin-dependent death in inner ear neurons.

Tauris J

The European Journal of Neuroscience, 33(4), 622-631 (2011)

Neurotensin modulates the migratory and inflammatory response of macrophages under hyperglycemic conditions.

Moura LI

BioMed Research International, 2013:941764 (2013)

ProNGF mediates death of Natural Killer cells through activation of the p75NTR-sortilin complex.

Rogers ML

Journal of Neuroimmunology, 226(1-2), 93-103 (2010)

Online CE-MALDI-TOF MS Using a Rotating Ball Interface

Musyimi HK, et al.

Analytical Chemistry, 76(19), 5968-5973 (2004)

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神经降压素

≥90% (HPLC)

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About This Item

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InChI

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说明

Amino Acid Sequence

一般描述

应用

生化/生理作用

安全信息

储存分类代码

WGK

闪点(°F)

闪点(°C)

个人防护装备

法规信息

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