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Merck
CN

N5751

Nω-硝基-L-精氨酸甲酯 盐酸盐

≥97% (TLC), powder, nitric oxide production inhibitor

别名:

L-NAME HCl, L-NAME 盐酸盐

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关于此项目

经验公式（希尔记法）:
C7H15N5O4 · HCl
化学文摘社编号:
51298-62-5
分子量:
269.69
NACRES:
NA.77
PubChem Substance ID:
24278011
UNSPSC Code:
12352209
EC Number:
257-116-1
MDL number:
MFCD00039052
Beilstein/REAXYS Number:
3744166

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产品名称

Nω-硝基-L-精氨酸甲酯 盐酸盐, ≥97% (TLC), powder

InChI key

QBNXAGZYLSRPJK-JEDNCBNOSA-N

InChI

1S/C7H15N5O4.ClH/c1-16-6(13)5(8)3-2-4-10-7(9)11-12(14)15;/h5H,2-4,8H2,1H3,(H3,9,10,11);1H/t5-;/m0./s1

SMILES string

Cl.COC(=O)[C@@H](N)CCCNC(=N)N[N+]([O-])=O

biological source

synthetic

assay

≥97% (TLC)

form

powder

color

white to off-white

mp

132 °C

solubility

H2O: 50 mg/mL

storage temp.

−20°C

Quality Level

200

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相关类别

Application

Nω-硝基-L-精氨酸甲酯盐酸盐已被用于：
  • 研究脑源性神经营养因子对大鼠皮层神经元神经毒性的影响
  • 研究其对远红外（FIR）增强大鼠皮肤微循环的影响
  • 研究其对瘦素诱导的小鼠肌细胞和脂肪细胞中肌肉因子III型纤连蛋白结构域包含蛋白5/鸢尾素调节的影响
  • 研究其对大鼠下丘脑室旁核和视上核细胞内精氨酸加压素和神经元型一氧化氮合酶mRNA水平的影响

Biochem/physiol Actions

抑制NO产生的精氨酸类似物。

General description

Nω-硝基-L-精氨酸甲酯盐酸盐或L -NAME HCl，一种抑制NO产生的精氨酸类似物。它对血管系统有多重作用。抑制乙酰胆碱引起的舒张，并引起动脉血压升高。用于预处理小鼠主动脉环制剂时，可取消卵磷脂化超氧化物歧化酶诱导的血管舒张作用。诱导白细胞粘附，增加微血管液以及蛋白质通量和渗透性。还用于许多学习和记忆研究。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCN3824
BCCN3823
BCCN0086
BCCM0361
BCCL3884

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. What is the solution stability of Product N5751, L-NAME hydrochloride?

    Although we do not perform solution stability studies, one literature reference recommends keeping solutions on ice during the course of one day.

  6. How do I sterilize a prepared solution of Product N5751, L-NAME hydrochloride?

    Solutions of this product may be sterile-filtered.

  7. Is Product N5751, L-NAME hydrochloride, an inhibitor of Nitric Oxide Synthase (NOS)?

    L-NAME was described as a reversible, non-specific inhibitor of nitric oxide synthase by Khavandgar. S. et al., Pharmacol. Biochem. Behav., 74, 795 (2003).

  8. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

L B Zou et al.
Neuropharmacology, 37(3), 323-330 (1998-07-29)
We investigated the role of nitric oxide (NO) in learning and memory formation in a radial maze test, by using the NO synthase (NOS) inhibitors, NG-nitro-L-arginine methyl ester (L-NAME) and 7-nitroindazole (7-NI), and an NO precursor, L-arginine. Rats were trained
P Kubes et al.
The American journal of physiology, 262(2 Pt 2), H611-H615 (1992-02-01)
We recently demonstrated that inhibitors of nitric oxide (NO) production cause a dramatic increase in leukocyte adherence and emigration in postcapillary venules. The objective of this study was to assess whether inhibition of NO production leads to vascular protein leakage
Lisa Nguy et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 304(9), R744-R752 (2013-03-22)
Rats with adenine-induced chronic renal failure (A-CRF) develop metabolic and cardiovascular abnormalities resembling those in patients with chronic kidney disease. The aim of this study was to investigate the mechanisms of hypertension in this model and to assess aortic stiffness
Protective effects of brain-derived neurotrophic factor against neurotoxicity of 3-nitropropionic acid in rat cortical neurons.
Wu CL, et al.
Neurotoxicology, 30(4), 718-726 (2009)
Amanda E Boe et al.
Circulation, 128(21), 2318-2324 (2013-10-05)
Long-term inhibition of nitric oxide synthase by L-arginine analogues such as N(ω)-nitro-l-arginine methyl ester (L-NAME) has been shown to induce senescence in vitro and systemic hypertension and arteriosclerosis in vivo. We previously reported that plasminogen activator inhibitor-1 (PAI-1)-deficient mice (PAI-1(-/-))
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Product Information Sheet - N5751

Product Information Sheet

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