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线性分子式:
O2N(CH2)2CO2H
化学文摘社编号:
分子量:
119.08
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
208-003-0
MDL number:
Beilstein/REAXYS Number:
1759889
产品名称
3-硝基丙酸, ≥97%
InChI key
WBLZUCOIBUDNBV-UHFFFAOYSA-N
InChI
1S/C3H5NO4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)
SMILES string
OC(CC[N+]([O-])=O)=O
biological source
synthetic
assay
≥97%
form
powder or crystals
color
white to light yellow
mp
68-70 °C (lit.)
solubility
alcohol: may be light yellow 100 mg/mL
storage temp.
2-8°C
Quality Level
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Application
3-硝基丙酸已用于:
- 建立大鼠的多系统萎缩-帕金森症(MSA-P)模型,评估其对胚胎纹状体和中脑移植物的影响
- 注入大鼠的黑质纹状体多巴胺能通路,研究其对多巴胺系统的特定作用
- 作为LUHMES神经元和细胞系的琥珀酸脱氢酶(SDH)抑制剂
Biochem/physiol Actions
兴奋性神经毒素,证明可引起类似于 Huntington 疾病的脑损伤。
内耳施用3-硝基丙酸(3-NP)会导致感音神经性听力损失。它可作为线粒体复合体II的不可逆抑制剂。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Mouse Models of Dystonia
Animal Models of Movement Disorders (2005)
No functional effects of embryonic neuronal grafts on motor deficits in a 3-nitropropionic acid rat model of advanced striatonigral degeneration (multiple system atrophy)
Waldner R, et al.
Neuroscience, 102(3), 581-592 (2001)
Dual loss of succinate dehydrogenase (SDH) and complex I activity is necessary to recapitulate the metabolic phenotype of SDH mutant tumors
Lorendeau D, et al.
Metabolic engineering, 43, 187-197 (2017)
Specific lesions in the extrapyramidal system of the rat brain induced by 3-nitropropionic acid (3-NPA)
Pei G and Ebendal T
Experimental Neurology, 132(1), 105-115 (1995)
The protective effect of Egb 761 against 3-nitropropionic acid-induced hearing loss: the role of sirtuin 1
Chang M Y, et al.
Clinical and Experimental Otorhinolaryngology, 11(1), 9-9 (2018)
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