推荐产品
产品名称
3-硝基丙酸, ≥97%
生物来源
synthetic
质量水平
方案
≥97%
表单
powder or crystals
颜色
white to light yellow
mp
68-70 °C (lit.)
溶解性
alcohol: may be light yellow 100 mg/mL
储存温度
2-8°C
SMILES字符串
OC(CC[N+]([O-])=O)=O
InChI
1S/C3H5NO4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)
InChI key
WBLZUCOIBUDNBV-UHFFFAOYSA-N
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应用
3-硝基丙酸已用于：
- 建立大鼠的多系统萎缩-帕金森症(MSA-P)模型，评估其对胚胎纹状体和中脑移植物的影响
- 注入大鼠的黑质纹状体多巴胺能通路，研究其对多巴胺系统的特定作用
- 作为LUHMES神经元和细胞系的琥珀酸脱氢酶(SDH)抑制剂
生化/生理作用
兴奋性神经毒素，证明可引起类似于 Huntington 疾病的脑损伤。
内耳施用3-硝基丙酸(3-NP)会导致感音神经性听力损失。它可作为线粒体复合体II的不可逆抑制剂。
警示用语：
Danger
危险声明
危险分类
Acute Tox. 3 Oral
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Mouse Models of Dystonia
Animal Models of Movement Disorders (2005)
The protective effect of Egb 761 against 3-nitropropionic acid-induced hearing loss: the role of sirtuin 1
Chang M Y, et al.
Clinical and Experimental Otorhinolaryngology, 11(1), 9-9 (2018)
Specific lesions in the extrapyramidal system of the rat brain induced by 3-nitropropionic acid (3-NPA)
Pei G and Ebendal T
Experimental Neurology, 132(1), 105-115 (1995)
No functional effects of embryonic neuronal grafts on motor deficits in a 3-nitropropionic acid rat model of advanced striatonigral degeneration (multiple system atrophy)
Waldner R, et al.
Neuroscience, 102(3), 581-592 (2001)
Dual loss of succinate dehydrogenase (SDH) and complex I activity is necessary to recapitulate the metabolic phenotype of SDH mutant tumors
Lorendeau D, et al.
Metabolic engineering, 43, 187-197 (2017)
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