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一般描述
NGF-β基因定位于人类染色体1p13.2。
重组人β-NGF在人293细胞中以120个氨基酸的同型二聚体（非二硫键）表达，计算分子量为13.5 kDa（单体）。神经生长因子β（β-NGF）是一种在结构上与BDNF、NT-3和NT-4相关的神经营养因子。天然β-NGF的产生发生在上皮细胞和脑下垂体中。
生化/生理作用
NGF-β基因的突变与疼痛感的丧失有关。
神经生长因子β（β-NGF）是一种有效的神经营养因子，通过其受体β-NGFR发出信号，在感觉和交感神经系统的发育和保存中起着至关重要的作用。β-NGF促进基底前脑胆碱能神经元的存活和胆碱能表型，并在体外刺激胚胎三叉神经运动神经元的神经突向外生长。
注意
产品在供应时可保持至少2年的活性。 初始解冻后，建议将蛋白以工作等分试样储存在-20℃下。
外形
该产品从PBS中冻干获得。
制备说明
打开前短暂离心小瓶。 建议在含有0.1%无内毒素重组人血清白蛋白的无菌DDW中复溶蛋白质，使其最终浓度为100 μg/mL。
储存及稳定性
将产品储存在-20°C下。产品在供应时可保持至少2年的活性。初始解冻后，建议将蛋白以工作等分试样储存在-20 °C下。
分析说明
通过人TF-1细胞（人红白血病指示细胞系）增殖的剂量依赖性刺激测定比活性。
免责声明
除非我们的目录中另有说明，否则我们的产品预期仅用于研究用途，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或对人类或动物的任何类型的消费或应用。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
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A Rosenthal et al.
Handbook of experimental pharmacology, 220, 497-512 (2014-03-29)
The neurotrophin family is comprised of the structurally related secreted proteins nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophine-4 (NT-4). They bind and activate the tyrosine kinase receptors Trk A, B, and C in a ligand-specific
S Soinila et al.
Neuroscience research, 6(2), 123-130 (1988-12-01)
Nerve growth factor (NGF)-like immunoreactivity was demonstrated in the rat pituitary intermediate lobe by indirect immunofluorescence method using antisera specific to beta-NGF isolated from adult male mouse submaxillary salivary gland. Co-culture of frozen or fresh intermediate lobes with newborn rat
Katherine M Nielsen et al.
Molecular and cellular neurosciences, 25(4), 629-641 (2004-04-15)
Developing neurons encounter a panoply of extracellular signals as they differentiate. A major goal is to identify these extrinsic cues and define the mechanisms by which neurons simultaneously integrate stimulation by multiple factors yet initiate one specific biological response. Factors
Yousong Su et al.
Progress in neuro-psychopharmacology & biological psychiatry, 104, 110015-110015 (2020-06-23)
The neurodevelopmental hypothesis of schizophrenia has been widely accepted. In light of our previous microarray data, two neurodevelopment-related genes were focused on inclduing the N-acylsphingosine amidohydrolase 1 gene (ASAH1) and the nerve growth factor gene (NGF). The evidence that ASAH1
Elisabet Einarsdottir et al.
Human molecular genetics, 13(8), 799-805 (2004-02-21)
Identification of genes associated with pain insensitivity syndromes can increase the understanding of the pathways involved in pain and contribute to the understanding of how sensory pathways relate to other neurological functions. In this report we describe the mapping and
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