生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
ascites fluid
抗体产品类型
primary antibodies
克隆
NE14, monoclonal
分子量
antigen apparent mol wt 200 kDa
包含
15 mM sodium azide as preservative
种属反应性
pig, mouse, chicken, bovine, guinea pig, rabbit, rat, human
增强验证
independent ( Antibodies)
Learn more about Antibody Enhanced Validation
技术
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:40
immunohistochemistry (frozen sections): suitable
microarray: suitable
western blot: suitable
同位素/亚型
IgG1
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... NEFH(4744)
相关类别
一般描述
单克隆抗神经丝 200（小鼠 IgM 同种型）来源于杂交瘤，该杂交瘤由小鼠骨髓瘤细胞与免疫小鼠脾细胞融合产生。神经丝是中间丝（IF）五种主要类型中的一种，主要存在于神经元起源的细胞或组织中。神经丝由三种主要蛋白组成，表观分子量分别为68 kD、160 kD和200 kD，相应命名为 NEFL（轻），NEFM（中）和 NEFH（重）。神经丝蛋白在神经元核周体中合成，组装形成丝，然后在轴突内缓慢地向突触末端移动。
免疫原
猪脊髓。
生化/生理作用
最近确定神经丝重链（NEFH）基因是引起常染色体显性遗传轴突腓骨肌萎缩症 （CMT2cc）的原因。此基因在散发性肌萎缩侧索硬化症（ALS）的发病机制中起作用。目前认为，神经丝多肽磷酸化可通过影响神经丝与细胞质细胞器之间的相互作用，调节其功能。
免责声明
除非我们的产品目录或产品随附的其他公司文件中另有说明，否则我们的产品仅用于研究用途，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、体外或体内治疗用途或任何类型的人类或动物消费或应用。
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WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
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