推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen ~230 kDa
antigen ~80 kDa
种属反应性
mouse, human, rat
浓度
~1 mg/mL
技术
immunohistochemistry: 1:100-1:200
western blot: 1:500-1:1,000
UniProt登记号
应用
research pathology
运输
dry ice
储存温度
−20°C
基因信息
human ... NOTCH4(4855)
mouse ... Notch4(18132)
rat ... Notch4(406162)
一般描述
NOTCH homolog-4 (NOTCH4) is expressed in breast cancer.
免疫原
synthetic peptide corresponding to residues 1506-1524 of human NOTCH4. This sequence is 89% identical in mouse and rat.
生化/生理作用
NOTCH homolog-4 (NOTCH4) has an intracellular domain which detaches from the protein on activation. This domain then translocates to the nucleus and modulates transcription of genes. NOTCH4 also activates various pathways and contributes to carcinogenesis. Mutations in the gene encoding the protein may be linked to schizophrenia.
外形
solution in phosphate buffered saline, containing 0.02% sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
NOTCH4 is a potential therapeutic target for triple-negative breast cancer.
Nagamatsu I
Anticancer Research, 34(1), 69-80 (2014)
Genetic variability testing of neurodevelopmental genes in schizophrenic patients.
Terzic T
Journal of Molecular Neuroscience, 56(1), 205-211 (2015)
AKT and 14-3-3 regulate Notch4 nuclear localization.
Ramakrishnan G
Scientific Reports, 5, 8782-8782 (2015)
Cuijuan Qian et al.
Molecular and cellular biochemistry, 401(1-2), 165-174 (2014-12-17)
Gastric cancer (GC) is one of the most common cancers and lethal malignancies in the world. Discovering novel biomarkers that correlate with GC may provide opportunities to reduce the severity of GC. As one of Notch receptor family members in
Fernanda Silva et al.
Oncology letters, 12(4), 2686-2691 (2016-10-05)
Epithelial ovarian cancer is the most lethal gynecologic malignancy, despite advances in treatment. The most common histological type, high-grade ovarian serous carcinoma (OSC) is usually diagnosed at an advanced stage, and although these types of tumors frequently respond to surgery
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