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N5131

Sigma-Aldrich

烟酰胺鸟嘌呤二核苷酸 钠盐

phospodiesterase and ADP-ribosyl cyclase substrate

别名:

3-(Aminocarbonyl)-1-[(2R,3R,4S,5R)-5-({[(S)-{[(S)-{[(2R,3S,4R,5R)-5-(2-Amino-6-Oxo-1,6-Dihydro-9h-Purin-9-Yl)-3,4-Dihydroxytetrahydrofuran-2-Yl]methoxy}(Hydroxy)phosphoryl]oxy} (Hydroxy)phosphoryl]ox, NGD

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About This Item

经验公式（希尔记法）:
C21H28N7O15P2
CAS号:
5624-35-1
分子量:
680.43
MDL编号:
MFCD00079505
UNSPSC代码:
41106305
PubChem化学物质编号:
24897721
NACRES:
NA.51

生物来源

yeast

质量水平

200

方案

≥-96%

表单

powder

溶解性

H2O: soluble-50 mg/mL, clear, almost colorless to slightly yellow

储存温度

−20°C

SMILES字符串

NC(=O)C1=CC=C[N](=C1)C2OC(COP(O)(=O)OP(O)(=O)OCC3OC(C(O)C3O)n4cnc5C(=O)N=C(N)Nc45)C(O)C2O

InChI

1S/C21H28N7O15P2/c22-16(33)8-2-1-3-27(4-8)19-14(31)12(29)9(41-19)5-39-44(35,36)43-45(37,38)40-6-10-13(30)15(32)20(42-10)28-7-24-11-17(28)25-21(23)26-18(11)34/h1-4,7,9-10,12-15,19-20,29-32H,5-6H2,(H2,22,33)(H,35,36)(H,37,38)(H3,23,25,26,34)

InChI key

WWXCUPZEUROLRY-UHFFFAOYSA-N

应用

烟酰胺鸟嘌呤二核苷酸 (NGD +) 可作为特异性蛇 竹叶青蛇 蛇毒磷酯酶的首选底物和研究 ADP-核糖环化酶 (s) 的特异性和动力学的底物。
烟酰胺鸟嘌呤二核苷酸钠盐已被用作测量分化 38 (CD38) 酶簇环化酶活性的底物。也用作荧光测定法测定 CD38/ADP-核糖 (ADPR) 活性的底物。

生化/生理作用

烟酰胺鸟嘌呤二核苷酸钠盐用于测定 ADP-核糖环化酶家族中生成环-ADP-核糖 (cADPR) 的蛋白质的活性。

其他说明

β 类似物-NAD

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H315,H319,H335

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

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分析证书(COA)

Lot/Batch Number
0000405991
0000394623
0000309547
0000309547
0000405991

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M E Migaud et al.
Biochemistry, 38(28), 9105-9114 (1999-07-22)
Readily synthesized nicotinamide adenine dinucleotide (NAD(+)) analogues have been used to investigate aspects of the cyclization of NAD(+) to cyclic adenosine 5'-O-diphosphate ribose (cADPR) catalyzed by the enzyme adenosine 5'-O-diphosphate (ADP) ribosyl cyclase and to produce the first potent inhibitors
Andrea Fabiano et al.
Visual neuroscience, 28(2), 121-128 (2011-01-29)
Cyclic ADP-ribose (cADPR) is a second messenger modulating intracellular calcium levels. We have previously described a cADPR-dependent calcium signaling pathway in bovine rod outer segments (ROS), where calcium ions play a pivotal role. ROS ADP-ribosyl cyclase (ADPR-cyclase) was localized in
M Liang et al.
Archives of biochemistry and biophysics, 371(2), 317-325 (1999-11-05)
Here we investigated whether cADPR and NAADP are synthesized in mitochondria. We found that ADPR-cyclase activity is present in mitochondria. In addition, we describe for the first time synthesis of NAADP in this intracellular organelle. ADPR-cyclase activities (V(MAX)) and NAADP
L G Mészáros et al.
Biochemical and biophysical research communications, 234(1), 252-256 (1997-05-08)
Two types of ADP-ribosyl cyclase activity were distinguished in dog and rat cardiac muscles by measuring the enzymatic conversion of NGD (as an NAD analog) into the fluorescent product cyclic GDP-ribose in cardiac muscle subcellular fractions. Both types of activity
Measuring CD38 Hydrolase and Cyclase Activities: 1, N6-Ethenonicotinamide Adenine Dinucleotide (varepsilon-NAD) and Nicotinamide Guanine Dinucleotide (NGD) Fluorescence-based Methods
de Oliveira GC, et al.
Bio-protocol, 8(14) (2018)
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