N4751
烟酰甘氨酸
别名:
Nicotinylglycine
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关于此项目
经验公式（希尔记法）:
C8H8N2O3
化学文摘社编号:
分子量:
180.16
NACRES:
NA.79
PubChem Substance ID:
UNSPSC Code:
12352106
EC Number:
209-497-0
MDL number:
InChI key
ZBSGKPYXQINNGF-UHFFFAOYSA-N
InChI
1S/C8H8N2O3/c11-7(12)5-10-8(13)6-2-1-3-9-4-6/h1-4H,5H2,(H,10,13)(H,11,12)
SMILES string
OC(=O)CNC(=O)c1cccnc1
assay
≥98% (with NaOH, titration)
form
powder
color
white
Biochem/physiol Actions
Nicotinuric acid (NUA) is a metabolite of niacin/vitamin B. Measurement of NUA levels in urine is used to indicate possible elevated nicotinamide adenine dinucleotide (NAD) catabolism. NUA may be used as a reference (standard curve) in the analysis of NAD and NUA catabolism. Nicotinic acid reduces triglycerides and increases high density lipoprotein(HDL) cholesterol.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
H L Figge et al.
Journal of clinical pharmacology, 28(12), 1136-1140 (1988-12-01)
We tested an inexpensive controlled-release nicotinic acid product (Bronson Pharmaceuticals, LaCanada, CA) and compared it with the standard, more expensive, controlled release product, Nicobid (Rorer Pharmaceuticals), by measuring the 24 hour urinary recovery of nicotinic and nicotinuric acids from ten
Effect of Nicotinic Acid (Vitamin B3 or Niacin) on the lipid profile of diabetic and non-diabetic rats
Shah TZ, et al.
Pakistan Journal of Medical Sciences, 29(5), 1259-1259 (2013)
Ines Reiche et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 26(1), 276-282 (2010-06-22)
Niaspan® is an extended-release formulation of nicotinic acid with improved tolerability compared with the immediate-release and sustained-release formulations. It is used to treat hypertriglyceridaemia with low high-density lipoprotein levels. This type of dyslipidaemia frequently appears in patients with chronic kidney
P J Neuvonen et al.
British journal of clinical pharmacology, 32(4), 473-476 (1991-10-01)
1. The bioavailability of three nicotinic acid formulations was investigated in a randomized cross-over study. 2. Single doses of nicotinic acid (500 mg) were given to seven healthy volunteers. The concentrations of nicotinic acid and its main metabolite nicotinuric acid
R H Stern et al.
Clinical pharmacology and therapeutics, 50(1), 66-70 (1991-07-01)
The mechanism of tolerance to nicotinic acid flushing was determined in subjects during a 5-day course of treatment. Objective measures of skin blood flow were used to confirm the development of tolerance. Plasma levels of nicotinic acid showed marked intraindividual
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