生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
种属反应性
mouse, rat, human
浓度
~1 mg/mL
技术
immunohistochemistry: 1:100-1:200
western blot: 1:1,000-1:2,000
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... NR4A2(4929)
mouse ... Pls3(18827)
rat ... Nr4a2(54278)
一般描述
Nur-related factor 1 (Nurr1) belongs to nuclear receptor super family. It is a brain-specific transcription factor, confined to central nervous system. Additionally, Nurr1 also modulates gene expression by repressing other transcriptional factors. Nurr1 is expressed in developing and mature dopamine neurons, hippocampus and cerebral cortex. It is crucial for the early development of dopamine neurons in midbrain during development, protection and survival of the neurons. Nurr1 may play a very critical role in the development of Parkinson′s disease and other neurodegenerative diseases and in human atherosclerotic lesions
Anti- Nurr1 recognizes human Nurr1.
Anti- Nurr1 recognizes human Nurr1.
免疫原
synthetic peptide corresponding to an internal sequence of human Nurr1.
应用
Anti-Nurr 1 antibody may be used in immunoblotting at a working dilution of 1:1000 to 1:2000. For immunohistochemistry the recommended dilution is 1:100 to 1:200.
外形
Solution in phosphate buffered saline, containing 0.02% sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
Asa Wallen-Mackenzie et al.
Genes & development, 17(24), 3036-3047 (2003-12-19)
The retinoid X receptor (RXR) is essential as a common heterodimerization partner of several nuclear receptors (NRs). However, its function as a bona fide receptor for endogenous ligands has remained poorly understood. Such a role would depend on the existence
Peter I Bonta et al.
Circulation, 121(18), 2023-2032 (2010-04-28)
Restenosis is the major drawback of percutaneous coronary interventions involving excessive activation and proliferation of vascular smooth muscle cells (SMCs). The nuclear receptor Nurr1 is an early response gene known mainly for its critical role in the development of dopamine
S W Law et al.
Molecular endocrinology (Baltimore, Md.), 6(12), 2129-2135 (1992-12-01)
We have identified and cloned a novel member of the nuclear receptor superfamily. The cDNA was isolated from a mouse brain cDNA library and encodes a protein 598 amino acids in length with a predicted mol wt of 66 kilodaltons.
Banafsheh Kadkhodaei et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 29(50), 15923-15932 (2009-12-18)
Transcription factors involved in the specification and differentiation of neurons often continue to be expressed in the adult brain, but remarkably little is known about their late functions. Nurr1, one such transcription factor, is essential for early differentiation of midbrain
Yinxiu Ding et al.
Molecular medicine reports, 14(3), 1993-1999 (2016-07-20)
Parkinson's disease (PD) is a severe neurodegenerative disorder. Although the detailed underlying molecular mechanism remains to be elucidated, the major pathological feature of PD is the loss of dopaminergic (DA) neurons of the substantia nigra. The use of donor stem
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