N4382
萘啶酸 钠盐
DNA gyrase inhibitor, powder
别名:
1-乙基-1,4-二氢-7-甲基-4-氧代-1,8-萘啶-3-羧酸 钠盐
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关于此项目
经验公式（希尔记法）:
C12H11N2NaO3
化学文摘社编号:
分子量:
254.22
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352106
EC Number:
222-159-7
MDL number:
Beilstein/REAXYS Number:
3580062
产品名称
萘啶酸 钠盐, powder
InChI key
ROKRAUFZFDQWLE-UHFFFAOYSA-M
InChI
1S/C12H12N2O3.Na/c1-3-14-6-9(12(16)17)10(15)8-5-4-7(2)13-11(8)14;/h4-6H,3H2,1-2H3,(H,16,17);/q;+1/p-1
SMILES string
[Na+].CCN1C=C(C([O-])=O)C(=O)c2ccc(C)nc12
form
powder
antibiotic activity spectrum
Gram-negative bacteria
Gram-positive bacteria
mode of action
DNA synthesis | interferes
enzyme | inhibits
originator
Sanofi Aventis
Quality Level
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General description
化学结构：喹诺酮类
萘啶酸是一种喹诺酮，通过抑制细菌II型拓扑异构酶的活性，阻断细菌复制。相较革兰氏阳性菌，它对革兰氏阴性菌有较强抗菌作用。萘啶酸已用于尿道感染治疗研究。
Application
萘啶酸已用于处理细菌培养物，研究它对肠道沙门菌和鼠伤寒沙门氏菌的抗性。
Biochem/physiol Actions
萘啶酸钠盐是细菌 DNA 聚合酶（DNA 旋转酶）和禽髓母细胞瘤病毒逆转录酶的抑制剂。在 酿酒酵母中抑制核酸和蛋白质合成。
Features and Benefits
该化合物由Sanofi Aventis开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。
这种化合物是细胞凋亡研究的特色产品。点击此处发现更多特色细胞凋亡产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Carc. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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