N4256
烟酸腺嘌呤二核苷酸 钠盐
≥98%
别名:
NAAD, NAAD钠盐, 烟酸NAD, 烟酸腺嘌呤二核苷酸钠盐, 脱酰氨NAD, 脱酰氨NAD钠盐
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关于此项目
经验公式（希尔记法）:
C21H25N6O15P2Na
化学文摘社编号:
分子量:
686.39
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
41106305
MDL number:
Form:
powder
Assay:
≥98%
Solubility:
H2O: soluble-50 mg/mL, clear, colorless
Biological source:
synthetic (inorganic)
InChI
1S/C21H27N6O15P2.Na.H/c22-17-12-18(24-7-23-17)27(8-25-12)20-16(31)14(29)11(41-20)6-39-44(36,37)42-43(34,35)38-5-10-13(28)15(30)19(40-10)26-3-1-2-9(4-26)21(32)33;;/h1-4,7-8,10-11,13-16,19-20,28-31H,5-6H2,(H,32,33)(H,34,35)(H,36,37)(H2,22,23,24);;
SMILES string
[Na].Nc1ncnc2n(cnc12)C3OC(COP(O)(=O)OP(O)(=O)OCC4OC(C(O)C4O)[N]5=CC(=CC=C5)C(O)=O)C(O)C3O
InChI key
JSOFOHZYBCRUNK-UHFFFAOYSA-N
biological source
synthetic (inorganic)
assay
≥98%
form
powder
solubility
H2O: soluble-50 mg/mL, clear, colorless
storage temp.
−20°C
Quality Level
General description
烟酸腺嘌呤二核苷酸（deamido-NAD、NAAD）是与NAD+密切相关的类似物。它用于研究烟酸单核苷酸腺苷转移酶（NMN/NaMN）的结构。NAAD可用作研究烟酰胺腺嘌呤二核苷酸合成酶（NAD）的特异性和动力学的底物。此外，它还被用作研究Sir2类NAD+-依赖型脱乙酰酶代谢的辅底物。
Application
烟酸腺嘌呤二核苷酸钠盐已被用作高效液相色谱（HPLC）代谢物测定的内标物。它还被用作烟酰胺腺嘌呤二核苷酸（NAD）生物合成的底物。
Other Notes
β-NAD类似物
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Hong Zhang et al.
Structure (London, England : 1993), 10(1), 69-79 (2002-02-14)
Nicotinamide/Nicotinate mononucleotide (NMN/NaMN) adenylyltransferase is an indispensable enzyme in both de novo biosynthesis and salvage of NAD+ and NADP+. In prokaryotes, it is absolutely required for cell survival, thus representing an attractive target for the development of new broad-spectrum antibacteria
Shanyun Lu et al.
Acta crystallographica. Section F, Structural biology and crystallization communications, 64(Pt 10), 893-898 (2008-10-22)
Nicotinic acid mononucleotide adenylyltransferase (NaMNAT; EC 2.7.7.18) is the penultimate enzyme in the biosynthesis of NAD(+) and catalyzes the adenylation of nicotinic acid mononucleotide (NaMN) by ATP to form nicotinic acid adenine dinucleotide (NaAD). This enzyme is regarded as a
Ralf Jauch et al.
The Journal of biological chemistry, 280(15), 15131-15140 (2005-02-09)
Nicotinamide adenine dinucleotide synthetases (NADS) catalyze the amidation of nicotinic acid adenine dinucleotide (NAAD) to yield the enzyme cofactor nicotinamide adenine dinucleotide (NAD). Here we describe the crystal structures of the ammonia-dependent homodimeric NADS from Escherichia coli alone and in
Alexei Gorelik et al.
The FEBS journal, 284(21), 3718-3726 (2017-09-13)
The ecto-nucleotide pyrophosphatase/phosphodiesterase (NPP) family of proteins mediates purinergic signaling by degrading extracellular nucleotides and also participates in phospholipid metabolism. NPP5 (ENPP5) is the least characterized member of this group and its specific role is unknown. This enzyme does not
Mechanism of sirtuin inhibition by nicotinamide: altering the NAD+ co-substrate specificity of a Sir2 enzyme
Avalos JL, et al.
Molecular Cell, 17(6), 855-868 (2005)
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