所有图片(2)
About This Item
经验公式（希尔记法）:
C21H25N6O15P2Na
CAS号:
分子量:
686.39
MDL编号:
UNSPSC代码:
41106305
PubChem化学物质编号:
NACRES:
NA.51
质量水平
检测方案
≥98%
形式
powder
储存温度
−20°C
SMILES字符串
[Na].Nc1ncnc2n(cnc12)C3OC(COP(O)(=O)OP(O)(=O)OCC4OC(C(O)C4O)[N]5=CC(=CC=C5)C(O)=O)C(O)C3O
InChI
1S/C21H27N6O15P2.Na.H/c22-17-12-18(24-7-23-17)27(8-25-12)20-16(31)14(29)11(41-20)6-39-44(36,37)42-43(34,35)38-5-10-13(28)15(30)19(40-10)26-3-1-2-9(4-26)21(32)33;;/h1-4,7-8,10-11,13-16,19-20,28-31H,5-6H2,(H,32,33)(H,34,35)(H,36,37)(H2,22,23,24);;
InChI key
JSOFOHZYBCRUNK-UHFFFAOYSA-N
一般描述
烟酸腺嘌呤二核苷酸（deamido-NAD、NAAD）是与NAD+密切相关的类似物。它用于研究烟酸单核苷酸腺苷转移酶（NMN/NaMN）的结构。NAAD可用作研究烟酰胺腺嘌呤二核苷酸合成酶（NAD）的特异性和动力学的底物。此外，它还被用作研究Sir2类NAD+-依赖型脱乙酰酶代谢的辅底物。
应用
烟酸腺嘌呤二核苷酸钠盐已被用作高效液相色谱（HPLC）代谢物测定的内标物。它还被用作烟酰胺腺嘌呤二核苷酸（NAD）生物合成的底物。
其他说明
β-NAD类似物
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Ralf Jauch et al.
The Journal of biological chemistry, 280(15), 15131-15140 (2005-02-09)
Nicotinamide adenine dinucleotide synthetases (NADS) catalyze the amidation of nicotinic acid adenine dinucleotide (NAAD) to yield the enzyme cofactor nicotinamide adenine dinucleotide (NAD). Here we describe the crystal structures of the ammonia-dependent homodimeric NADS from Escherichia coli alone and in
Alexei Gorelik et al.
The FEBS journal, 284(21), 3718-3726 (2017-09-13)
The ecto-nucleotide pyrophosphatase/phosphodiesterase (NPP) family of proteins mediates purinergic signaling by degrading extracellular nucleotides and also participates in phospholipid metabolism. NPP5 (ENPP5) is the least characterized member of this group and its specific role is unknown. This enzyme does not
Mechanism of sirtuin inhibition by nicotinamide: altering the NAD+ co-substrate specificity of a Sir2 enzyme
Avalos JL, et al.
Molecular Cell, 17(6), 855-868 (2005)
The SARM1 toll/interleukin-1 receptor domain possesses intrinsic NAD+ cleavage activity that promotes pathological axonal degeneration
Essuman K, et al.
Neuron, 93(6), 1334-1343 (2017)
Hong Zhang et al.
Structure (London, England : 1993), 10(1), 69-79 (2002-02-14)
Nicotinamide/Nicotinate mononucleotide (NMN/NaMN) adenylyltransferase is an indispensable enzyme in both de novo biosynthesis and salvage of NAD+ and NADP+. In prokaryotes, it is absolutely required for cell survival, thus representing an attractive target for the development of new broad-spectrum antibacteria
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