所有图片(2)
About This Item
经验公式（希尔记法）:
C10H16N4O7S
CAS号:
分子量:
336.32
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.32
推荐产品
质量水平
方案
≥97%
表单
powder
溶解性
water: soluble 19.60-20.40 mg/mL
储存温度
−20°C
SMILES字符串
N[C@@H](CCC(=O)N[C@@H](CSN=O)C(=O)NCC(O)=O)C(O)=O
InChI
1S/C10H16N4O7S/c11-5(10(19)20)1-2-7(15)13-6(4-22-14-21)9(18)12-3-8(16)17/h5-6H,1-4,11H2,(H,12,18)(H,13,15)(H,16,17)(H,19,20)/t5-,6-/m0/s1
InChI key
HYHSBSXUHZOYLX-WDSKDSINSA-N
一般描述
S-亚硝基谷胱甘肽（GSNO）是一种内源性氮氧化物，在肺和脑的细胞外液中高表达。
应用
S-亚硝基谷胱甘肽（GSNO）已用作：
- 作为反相色谱的标准品，与化学蒸汽发生和原子荧光检测器（RPC-CVGAFS）和反相色谱荧光（RPC-FD）相结合。
- 作为分光光度法和高效液相色谱（HPLC）测定的标准品。
生化/生理作用
S-亚硝基谷胱甘肽（GSNO）抑制兔骨骼肌中肌浆网结合肌酸激酶的活性，并最终减少肌浆网囊泡中 ATP 驱动的 Ca2+ 摄取。气道细胞中的 GSNO 使气道平滑肌松弛并增强气道纤毛运动。它还阻断气道上皮阿米洛利敏感的钠转运，同时刺激钙依赖性上皮细胞氯转运并诱导中性粒细胞凋亡。此外，它还具有抗菌活性。囊性纤维化（CF）气道中 GSNO 浓度低。它是NO供体，可作为平滑肌松弛剂和血管扩张剂，并且能抑制体内的血小板活化。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Acute effects of aerosolized S-nitrosoglutathione in cystic fibrosis.
Snyder AH
American Journal of Respiratory and Critical Care Medicine, 165(7), 922-926 (2002)
Inhibition of creatine kinase by S-nitrosoglutathione.
Wolosker H
Febs Letters, 392(3), 274-276 (1996)
C A Staab et al.
Cellular and molecular life sciences : CMLS, 65(24), 3950-3960 (2008-11-18)
Alcohol dehydrogenase 3 (ADH3) is highly conserved, ubiquitously expressed in mammals and involved in essential cellular pathways. A large active site pocket entails special substrate specificities: shortchain alcohols are poor substrates, while medium-chain alcohols and particularly the glutathione adducts S-hydroxymethylglutathione
Shuangchen Chen et al.
Frontiers in plant science, 8, 1109-1109 (2017-07-18)
Ubiquitination is a common regulatory mechanism, playing a critical role in diverse cellular and developmental processes in eukaryotes. However, a few reports on the functional correlation between E3 ubiquitin ligases and reactive oxygen species (ROS) or reactive nitrogen species (RNS)
Yu-Chen Yang et al.
Antioxidants & redox signaling, 18(10), 1129-1140 (2012-09-25)
Both cancer-suppressing and cancer-promoting properties of reactive nitrogen and oxygen species (RNOS) have been suggested to play a role in tumor pathology, particularly those activities associated with chronic inflammation. Here, we address the impact of nitric oxide (NO) on the
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