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Merck
CN
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安全信息

N4143

Sigma-Aldrich

Neurokinin B

≥95% (HPLC)

别名:

β-Neurokinin, Neuromedin K

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About This Item

经验公式（希尔记法）:
C55H79N13O14S2
CAS号:
86933-75-7
分子量:
1210.42
MDL编号:
MFCD00133665
UNSPSC代码:
51111800
PubChem化学物质编号:
24897694
NACRES:
NA.32

质量水平

200

方案

≥95% (HPLC)

表单

powder

UniProt登记号

Q9UHF0

储存温度

−20°C

SMILES字符串

CSCCC(NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(NC(=O)C(Cc1ccccc1)NC(=O)C(Cc2ccccc2)NC(=O)C(CC(O)=O)NC(=O)C(Cc3cnc[nH]3)NC(=O)C(CCSC)NC(=O)C(N)CC(O)=O)C(C)C)C(N)=O

InChI

1S/C55H79N13O14S2/c1-30(2)21-38(50(77)62-36(47(57)74)17-19-83-5)61-43(69)28-59-55(82)46(31(3)4)68-54(81)40(23-33-15-11-8-12-16-33)65-51(78)39(22-32-13-9-7-10-14-32)64-53(80)42(26-45(72)73)67-52(79)41(24-34-27-58-29-60-34)66-49(76)37(18-20-84-6)63-48(75)35(56)25-44(70)71/h7-16,27,29-31,35-42,46H,17-26,28,56H2,1-6H3,(H2,57,74)(H,58,60)(H,59,82)(H,61,69)(H,62,77)(H,63,75)(H,64,80)(H,65,78)(H,66,76)(H,67,79)(H,68,81)(H,70,71)(H,72,73)

InChI key

NHXYSAFTNPANFK-UHFFFAOYSA-N

基因信息

human ... TAC3(6866)

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Amino Acid Sequence

Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met-NH2

生化/生理作用

Neurokinin B is a ten-residue peptide. It is an endogenous tachykinin agonist with preference for the NK-3 receptor. It is a potent bronchoconstrictor and may have a neuromodulatory role in the brain. Neurokinin B has a role in slow synaptic or non-synaptic communication.

其他说明

Lyophilized from 0.1% TFA in H2O

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

监管及禁止进口产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000226747
0000226749
0000226538
0000215824
0000215824

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Robert P Millar et al.
Nature reviews. Endocrinology, 9(8), 451-466 (2013-07-03)
Reproductive hormones affect all stages of life from gamete production, fertilization, fetal development and parturition, neonatal development and puberty through to adulthood and senescence. The reproductive hormone cascade has, therefore, been the target for the development of numerous drugs that
Emilie Caron et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(33), 11486-11494 (2012-08-17)
It is increasingly accepted that alterations of the early life environment may have lasting impacts on physiological functions. In particular, epidemiological and animal studies have indicated that changes in growth and nutrition during childhood and adolescence can impair reproductive function.
Neurokinin B- and specific tachykinin NK3 receptor agonists-induced airway hyperresponsiveness in the guinea-pig
Samira D
British Journal of Pharmacology (2000)
The Tachykinin Peptide Neurokinin B Binds Copper Forming an Unusual [CuII(NKB)2] Complex and Inhibits Copper Uptake into 1321N1 Astrocytoma Cells
ACS Chemical Neuroscience (2013)
Neurokinin B Acts via the Neurokinin-3 Receptor in the Retrochiasmatic Area to Stimulate Luteinizing Hormone Secretion in Sheep
Endocrinology (2010)
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