推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
种属反应性
rat
增强验证
functional assay
Learn more about Antibody Enhanced Validation
技术
immunohistochemistry (frozen sections): 1:10,000 using rat brain
indirect immunofluorescence: 1:500 using NGF-treated PC12 cells
microarray: suitable
western blot: 1:5,000 using whole cell extract of NGF-treated PC12 cells
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
rat ... Ngfr(24596)
一般描述
Nerve growth factor receptor (NGFR) is encoded by the gene mapped to rat chromosome 10. In rats, immunoreactivity of NGFR has been observed in neuronal cell bodies, axons and/or dendrites of cholinergic and non-cholinergic structures of the brain.
Peptide sequence of the antigen is highly conserved in human (single amino acid substitution) and chicken NGFR p75.
免疫原
synthetic peptide corresponding to the C-terminal of NGFR p75 of rat origin (amino acids 407-425 with N-terminally added lysine) conjugated to KLH.
应用
Anti-Nerve growth factor receptor (NGFR p75) antibody produced in rabbit has been used in:
- immunoprecipitation
- immunocytochemistry
- immunohistochemistry
- immunoblotting
生化/生理作用
Neurotrophins (NT) are growth factors that are essential for the development and maintenance of the nervous system. One of the receptors that mediate the effects of NTs is the Nerve Growth Factor Receptor/TNFRSF16 (p75NGFR, p75NTR). NGFR mediates the effects of NGF that are important in the survival and differentiation of neurons and neural crest-derived cells, during embryonic and early postnatal development. Expression of NGFR has been associated with favorable prognosis and survival in breast and pancreatic cancers.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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产品编号
说明
价格
储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
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常规特殊物品
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分析证书(COA)
Lot/Batch Number
D Rebmann et al.
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C O Hanemann et al.
Neuropathology and applied neurobiology, 32(6), 605-614 (2006-11-07)
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Yan Chen et al.
Medical science monitor : international medical journal of experimental and clinical research, 21, 3608-3615 (2015-11-22)
Alzheimer's disease (AD) is the most common type of dementia. It causes progressive brain disorder involving loss of normal memory and thinking skills. The transplantation of neural stem cells (NSCs) has been reported to improve learning and memory function of
Soheila Pourkhodadad et al.
Cell journal, 21(2), 220-228 (2019-03-03)
Traumatic spinal cord injury (SCI) is considered one of the most devastating injuries leading to neuronal disruption. Olfactory ensheathing cells (OECs) and minocycline have been shown to promote locomotor function after spinal cord injury. In this study, we have tested
Markus Tammia et al.
Heliyon, 4(11), e00982-e00982 (2019-02-15)
Schwann cells are key players in peripheral nerve regeneration, and are uniquely capable of remyelinating axons in this context. Schwann cells orchestrate this process via a set of transcription factors. While it has been shown that overexpression of specific genes
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