N3908
Anti-Nerve Growth Factor Receptor (NGFR p75) antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
别名:
NGFR Antibody - Anti-Nerve Growth Factor Receptor (NGFR p75) antibody produced in rabbit, Ngfr Antibody
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关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
immunohistochemistry (frozen sections)
indirect immunofluorescence
microarray
western blot
indirect immunofluorescence
microarray
western blot
Species reactivity:
rat
Citations:
22
Technique(s):
immunohistochemistry (frozen sections): 1:10,000 using rat brain
indirect immunofluorescence: 1:500 using NGF-treated PC12 cells
microarray: suitable
western blot: 1:5,000 using whole cell extract of NGF-treated PC12 cells
indirect immunofluorescence: 1:500 using NGF-treated PC12 cells
microarray: suitable
western blot: 1:5,000 using whole cell extract of NGF-treated PC12 cells
Uniprot accession no.:
产品名称
Anti-Nerve Growth Factor Receptor (NGFR p75) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
rat
enhanced validation
functional assay
Learn more about Antibody Enhanced Validation
technique(s)
immunohistochemistry (frozen sections): 1:10,000 using rat brain
indirect immunofluorescence: 1:500 using NGF-treated PC12 cells
microarray: suitable
western blot: 1:5,000 using whole cell extract of NGF-treated PC12 cells
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
rat ... Ngfr(24596)
Immunogen
synthetic peptide corresponding to the C-terminal of NGFR p75 of rat origin (amino acids 407-425 with N-terminally added lysine) conjugated to KLH.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.
Application
Anti-Nerve growth factor receptor (NGFR p75) antibody produced in rabbit has been used in:
- immunoprecipitation
- immunocytochemistry
- immunohistochemistry
- immunoblotting
Biochem/physiol Actions
Neurotrophins (NT) are growth factors that are essential for the development and maintenance of the nervous system. One of the receptors that mediate the effects of NTs is the Nerve Growth Factor Receptor/TNFRSF16 (p75NGFR, p75NTR). NGFR mediates the effects of NGF that are important in the survival and differentiation of neurons and neural crest-derived cells, during embryonic and early postnatal development. Expression of NGFR has been associated with favorable prognosis and survival in breast and pancreatic cancers.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Nerve growth factor receptor (NGFR) is encoded by the gene mapped to rat chromosome 10. In rats, immunoreactivity of NGFR has been observed in neuronal cell bodies, axons and/or dendrites of cholinergic and non-cholinergic structures of the brain.
Peptide sequence of the antigen is highly conserved in human (single amino acid substitution) and chicken NGFR p75.
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存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Yan Chen et al.
Medical science monitor : international medical journal of experimental and clinical research, 21, 3608-3615 (2015-11-22)
Alzheimer's disease (AD) is the most common type of dementia. It causes progressive brain disorder involving loss of normal memory and thinking skills. The transplantation of neural stem cells (NSCs) has been reported to improve learning and memory function of
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Cell journal, 21(2), 220-228 (2019-03-03)
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C O Hanemann et al.
Neuropathology and applied neurobiology, 32(6), 605-614 (2006-11-07)
The NF2 gene encodes the tumour suppressor protein merlin. The mutation of a single allele of this gene causes the autosomal dominantly inherited disease neurofibromatosis type 2 (NF2), which is characterized mainly by vestibular schwannoma carrying a second hit mutation.
D Rebmann et al.
Journal of orthopaedic surgery and research, 15(1), 270-270 (2020-07-19)
Sensory nerve endings in ligaments play an important role for the proprioceptive function. Clinical trials show that the sense of body position does not fully recover in the knee joint after reconstructive surgery of the ruptured anterior cruciate ligament. The
Myeongjeong Choo et al.
Nature communications, 8(1), 195-195 (2017-08-05)
Elimination of early-formed redundant synapses during postnatal development is essential for functional neural circuit formation. Purkinje cells (PCs) in the neonatal cerebellum are innervated by multiple climbing fibers (CFs). A single CF is strengthened whereas the other CFs are eliminated
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