N3905
尼卡巴嗪
别名:
N,N′-尼卡巴嗪
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关于此项目
经验公式（希尔记法）:
C13H10N4O5 · C6H8N2O
化学文摘社编号:
分子量:
426.38
NACRES:
NA.85
PubChem Substance ID:
UNSPSC Code:
51102829
EC Number:
206-359-1
MDL number:
InChI key
UKHWDRMMMYWSFL-UHFFFAOYSA-N
InChI
1S/C13H10N4O5.C6H8N2O/c18-13(14-9-1-5-11(6-2-9)16(19)20)15-10-3-7-12(8-4-10)17(21)22;1-4-3-5(2)8-6(9)7-4/h1-8H,(H2,14,15,18);3H,1-2H3,(H,7,8,9)
SMILES string
Cc1cc(C)nc(O)n1.[O-][N+](=O)c2ccc(NC(=O)Nc3ccc(cc3)[N+]([O-])=O)cc2
form
powder
antibiotic activity spectrum
parasites
mode of action
cell membrane | interferes
Quality Level
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Application
尼卡巴嗪是养鸡业中的一种球虫抑制剂（抗原虫药），是加拿大鹅和水禽的避孕药。用于研究鸟类繁殖，干扰鸟类蛋中卵黄（卵黄）膜的形成。已用于研究递送方法如何影响 4,4′ 的血浆水平-二硝基卡巴腈 (DNC)，是尼卡巴嗪的活性抗球虫成分 。
Biochem/physiol Actions
尼卡巴嗪通过降低产蛋量、蛋重和种蛋孵化率影响禽类繁殖。尼卡巴嗪的操作机制尚不清楚。
Other Notes
保存于密闭容器内，置于干燥通风处。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
V Gaudin et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 877(23), 2358-2362 (2009-04-07)
Nicarbazin, a coccidiostat, is used as a feed additive in poultry but not in laying hens. Feed contamination may however occur resulting in residues being present in eggs. As a Maximum Residue Limit (MRL) does not exist for nicarbazin residues
Martin Danaher et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 25(1), 32-40 (2007-10-25)
A survey was carried out on the occurrence of dinitrocarbanilide (DNC), the marker residue for nicarbazin, in poultry produced in Ireland during 2002-2004. Liver (n = 736) and breast muscle samples (n = 342) were tested. DNC residues were found
Katrina Campbell et al.
Journal of agricultural and food chemistry, 55(6), 2497-2503 (2007-02-27)
Concentrations of the coccidiostat nicarbazin as low as 2 mg/kg in feed can result in violative drug residues arising in poultry liver. A lateral flow device (LFD) was developed for the detection of contaminating concentrations of nicarbazin following solvent extraction
A-C Huet et al.
Food additives and contaminants, 22(2), 128-134 (2005-04-13)
Nicarbazin and halofuginone have been widely used as coccidiostats for the prevention and treatment of coccidiosis in poultry. It has been shown that accidental cross-contamination of feed can lead to residues of these compounds in eggs and/or muscle. This paper
Virve Hagren et al.
Journal of agricultural and food chemistry, 52(9), 2429-2433 (2004-04-29)
An automated immunoassay for the detection of nicarbazin residues in poultry eggs and liver was developed. The assay was based on a novel all-in-one dry chemistry concept and time-resolved fluorometry. The analyte specific antibody was immobilized into a single microtiter
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