形式
solid
质量水平
药品控制
USDEA Schedule IV; Home Office Schedule 4.1; psychotrope (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)
SMILES字符串
[O-][N+](=O)c1ccc2NC(=O)CN=C(c3ccccc3)c2c1
InChI
1S/C15H11N3O3/c19-14-9-16-15(10-4-2-1-3-5-10)12-8-11(18(20)21)6-7-13(12)17-14/h1-8H,9H2,(H,17,19)
InChI key
KJONHKAYOJNZEC-UHFFFAOYSA-N
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生化/生理作用
Hypnotic; ligand for the GABAA receptor benzodiazepine modulatory site.
N Inazu et al.
Biochemical pharmacology, 52(10), 1585-1591 (1996-11-22)
We investigated the effects of minor and major tranquilizers on ovarian and adrenal aldo-keto reductase activity towards five substrates in relation to ovulation in mature cycling rats. Nitrazepam (NZP) did not alter ovarian and adrenal weights or body weight, although
J Liu et al.
Journal of pharmaceutical sciences, 87(12), 1632-1638 (1999-04-03)
The purpose of this research was to investigate the influence of surfactants on the dissolution of benzodiazepines in interactive mixtures. The dissolution of ternary interactive mixtures consisting of micronized drugs (oxazepam, nitrazepam, and flunitrazepam) and micronized surfactants (sodium lauryl sulfate
Masatomo Suetsugi et al.
Progress in neuro-psychopharmacology & biological psychiatry, 31(4), 839-847 (2007-03-03)
The first-night effect is a well-known phenomenon that is considered to result from a subject's lack of adaptation to the unfamiliar environment of a sleep laboratory and to the technical equipment used for polysomnography. The effect has been explored as
Mihalj Poša et al.
Colloids and surfaces. B, Biointerfaces, 86(2), 285-291 (2011-05-07)
The formation of mixed micelles built of 7,12-dioxolithocholic and the following hydrophobic bile acids was examined by conductometric method: cholic (C), deoxycholic (D), chenodeoxycholic (CD), 12-oxolithocholic (12-oxoL), 7-oxolithocholic (7-oxoL), ursodeoxycholic (UD) and hiodeoxycholic (HD). Interaction parameter (β) in the studied
Mihalj Posa et al.
Colloids and surfaces. B, Biointerfaces, 74(1), 84-90 (2009-07-28)
Critical micellear concentrations (CMC) were determined for two novel promoters of membrane permeability-7-monoketocholic acid (7-MKC) and 12-monoketocholic acid (12-MKC), using two non-invasive ((1)H NMR relaxation experiment and conductometry) and two invasive (spectral shift and partition coefficient of the probe molecule)
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