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表单
powder
质量水平
抗生素抗菌谱
parasites
作用机制
enzyme | inhibits
SMILES字符串
Oc1ccc(Cl)cc1C(=O)Nc2ccc(cc2Cl)[N+]([O-])=O
InChI
1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
InChI key
RJMUSRYZPJIFPJ-UHFFFAOYSA-N
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应用
氯硝柳胺是驱虫药系列中的特尼酰胺。它能帮助感染人有效对抗绦虫。氯硝柳胺用于研究Wnt / Frizzled-1信号传导途径。它用于抑制NF-κB转录和DNA结合，并提高ROS水平，诱导急性髓性白血病（AML）细胞凋亡。
生化/生理作用
氯硝柳胺解偶联绦虫氧化磷酸化，抑制寄生蠕虫线粒体氧化磷酸化。它阻断肿瘤坏死因子诱导的 IκBα 磷酸化、p65 的转位和 AML 细胞中 NF-κβ 调节基因的表达。
其他说明
50g及250g
将容器密闭保存在干燥和通风良好的地方。在干燥处保存。
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
农药列管产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Mechanism of action of reagents that uncouple oxidative phosphorylation.
E C Weinbach et al.
Nature, 221(5185), 1016-1018 (1969-03-15)
Yanli Jin et al.
Cancer research, 70(6), 2516-2527 (2010-03-11)
NF-kappaB may be a potential therapeutic target for acute myelogenous leukemia (AML) because NF-kappaB activation is found in primitive human AML blast cells. In this report, we initially discovered that the potent antineoplastic effect of niclosamide, a Food and Drug
Masanori Ono et al.
Fertility and sterility, 101(5), 1441-1449 (2014-02-19)
To assess the effect of three WNT/β-catenin pathway inhibitors-inhibitor of β-catenin and TCF4 (ICAT), niclosamide, and XAV939-on the proliferation of primary cultures of human uterine leiomyoma cells. Prospective study of human leiomyoma cells obtained from myomectomy or hysterectomy. University research
Wenyan Lu et al.
PloS one, 6(12), e29290-e29290 (2011-12-24)
The Wnt/β-catenin signaling pathway is important for tumor initiation and progression. The low density lipoprotein receptor-related protein-6 (LRP6) is an essential Wnt co-receptor for Wnt/β-catenin signaling and represents a promising anticancer target. Recently, the antihelminthic drug, niclosamide was found to
K Ketola et al.
British journal of cancer, 106(1), 99-106 (2012-01-05)
We have shown that a sodium ionophore monensin inhibits prostate cancer cell growth. A structurally related compound to monensin, salinomycin, was recently identified as a putative cancer stem cell inhibitor. The growth inhibitory potential of salinomycin was studied in a
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